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Department of Cell Biology,
Cardiovascular Research Center
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Ebolavirus entry requires a compact hydrophobic fist at the tip of the fusion loop.
Journal of virology Jun, 2014 | Pubmed ID: 24696482
Ebola virus and severe acute respiratory syndrome coronavirus display late cell entry kinetics: evidence that transport to NPC1+ endolysosomes is a rate-defining step.
Journal of virology Mar, 2015 | Pubmed ID: 25552710
The Roles of Histidines and Charged Residues as Potential Triggers of a Conformational Change in the Fusion Loop of Ebola Virus Glycoprotein.
PloS one , 2016 | Pubmed ID: 27023721
Mapping of Ebolavirus Neutralization by Monoclonal Antibodies in the ZMapp Cocktail Using Cryo-Electron Tomography and Studies of Cellular Entry.
Journal of virology 09, 2016 | Pubmed ID: 27279622
Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion.
Journal of virology 10, 2016 | Pubmed ID: 27466418
Clomiphene and Its Isomers Block Ebola Virus Particle Entry and Infection with Similar Potency: Potential Therapeutic Implications.
Viruses 08, 2016 | Pubmed ID: 27490565
The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection.
PLoS neglected tropical diseases 04, 2017 | Pubmed ID: 28403145
Structure of the Ebola virus envelope protein MPER/TM domain and its interaction with the fusion loop explains their fusion activity.
Proceedings of the National Academy of Sciences of the United States of America 09, 2017 | Pubmed ID: 28874543
Identification of Combinations of Approved Drugs With Synergistic Activity Against Ebola Virus in Cell Cultures.
The Journal of infectious diseases 11, 2018 | Pubmed ID: 29939303
Glucosylceramidase Maintains Influenza Virus Infection by Regulating Endocytosis.
Journal of virology 06, 2019 | Pubmed ID: 30918081
An exploration of conditions proposed to trigger the Ebola virus glycoprotein for fusion.
PloS one , 2019 | Pubmed ID: 31276481
Ebola virus glycoprotein interacts with cholesterol to enhance membrane fusion and cell entry.
Nature structural & molecular biology 02, 2021 | Pubmed ID: 33462517
Inhibition of Arenaviruses by Combinations of Orally Available Approved Drugs.
Antimicrobial agents and chemotherapy 03, 2021 | Pubmed ID: 33468464
University of Virginia
Elizabeth A. Nelson1,2,
Jingyao Qiu3,4,
Nicholas W. Chavkin1,2,
Karen K. Hirschi1,2,3,4,5
1Department of Cell Biology, University of Virginia,
2Cardiovascular Research Center, University of Virginia,
3Department of Medicine, Yale University School of Medicine,
4Department of Genetics, Yale University School of Medicine,
5Yale Cardiovascular Research Center, Yale University School of Medicine
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