Elena S. Pak
Department of Physiology
East Carolina University
Elena Pak is a Research Specialist in the Department of Physiology, East Carolina University in Greenville, North Carolina. She received her Bachelor with honor degree and Master in Physiology from Almaty State University in Kazakhstan.
She was trained later in Melbourne University, Australia studying beta-adrenoceptor pharmacology in heart using autoradiography technique and then in Columbia University, New York studying physiological function of beta-2 adrenergic receptors in the neonatal and adult rat ventricular myocytes.
She then moved to East Carolina University in Greenville, North Carolina where she continued her research at Dr. A. Murashov’s laboratory focusing on studying of microRNAs role in transgenerational effect of diets and exercise on offspring susceptibility to neurological and metabolic disorders using genomic, proteomic approaches as well as genetically manipulated Drosophila and mouse models.
Effect of 17 beta-estradiol on gene expression in lumbar spinal cord following sciatic nerve crush injury in ovariectomized mice.
Brain research Mar, 2003 | Pubmed ID: 12646309
Differential expression of endothelin receptors in regenerating spinal motor neurons in mice.
Brain research. Molecular brain research Aug, 2003 | Pubmed ID: 12941473
Transplantation of neuronal and glial precursors dramatically improves sensorimotor function but not cognitive function in the traumatically injured brain.
Journal of neurotrauma Feb, 2004 | Pubmed ID: 15000757
Estrogen increases retrograde labeling of motoneurons: evidence of a nongenomic mechanism.
American journal of physiology. Cell physiology Aug, 2004 | Pubmed ID: 15044155
17beta-Estradiol enhances neuronal differentiation of mouse embryonic stem cells.
FEBS letters Jul, 2004 | Pubmed ID: 15225627
Induction of VEGF and its Flt-1 receptor after sciatic nerve crush injury.
Neuroreport Sep, 2004 | Pubmed ID: 15486493
Directed differentiation of embryonic stem cells into dorsal interneurons.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Feb, 2005 | Pubmed ID: 15545303
Parallel development of cardiomyocytes and neurons in embryonic stem cell culture.
Biochemical and biophysical research communications Jul, 2005 | Pubmed ID: 15894285
Predifferentiated embryonic stem cells prevent chronic pain behaviors and restore sensory function following spinal cord injury in mice.
Molecular medicine (Cambridge, Mass.) Jan-Mar, 2006 | Pubmed ID: 16838066
RNAi pathway is functional in peripheral nerve axons.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Mar, 2007 | Pubmed ID: 17209129
Pre-differentiated embryonic stem cells promote neuronal regeneration by cross-coupling of BDNF and IL-6 signaling pathways in the host tissue.
Journal of neurotrauma Jul, 2009 | Pubmed ID: 19138107
Embryonic stem cells inhibit expression of erythropoietin in the injured spinal cord.
Neuroscience letters Jan, 2011 | Pubmed ID: 21056627
Multi-walled carbon nanotubes inhibit regenerative axon growth of dorsal root ganglia neurons of mice.
Neuroscience letters Jan, 2012 | Pubmed ID: 22172934
Neurogenic potential of spinal cord organotypic culture.
Neuroscience letters May, 2015 | Pubmed ID: 25805458
Paternal long-term exercise programs offspring for low energy expenditure and increased risk for obesity in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Feb, 2016 | Pubmed ID: 26506979
NLRP3/IL-1β mediates denervation during bladder outlet obstruction in rats.
Neurourology and urodynamics 03, 2018 | Pubmed ID: 28984997
Enhanced Electrical Field Stimulated Nitrergic and Purinergic Vasoreactivity in Distal vs Proximal Internal Pudendal Arteries.
The journal of sexual medicine 11, 2017 | Pubmed ID: 29110801
miRNA-431 Prevents Amyloid-β-Induced Synapse Loss in Neuronal Cell Culture Model of Alzheimer's Disease by Silencing Kremen1.
Frontiers in cellular neuroscience , 2018 | Pubmed ID: 29643768
Clarifying the Relative Impacts of Vascular and Nerve Injury That Culminate in Erectile Dysfunction in a Pilot Study Using a Rat Model of Prostate Irradiation and a Thrombopoietin Mimetic.
International journal of radiation oncology, biology, physics 04, 2019 | Pubmed ID: 30529374
Prostate-Confined Radiation Decreased Pelvic Ganglia Neuronal Survival and Outgrowth.
The journal of sexual medicine Jan, 2019 | Pubmed ID: 30621923
Chronic high-fat diet decreased detrusor mitochondrial respiration and increased nerve-mediated contractions.
Neurourology and urodynamics 08, 2019 | Pubmed ID: 31074529
Ex Vivo Radiation Leads to Opposing Neurite Growth in Whole Ganglia vs Dissociated Cultured Pelvic Neurons.
The journal of sexual medicine 08, 2020 | Pubmed ID: 32576498
Preference and detrimental effects of high fat, sugar, and salt diet in wild-caught Drosophila simulans are reversed by flight exercise.
FASEB bioAdvances Jan, 2021 | Pubmed ID: 33490883
High-fat diet induces obesity in adult mice but fails to develop pre-penile and penile vascular dysfunction.
International journal of impotence research May, 2021 | Pubmed ID: 33947973
Impact of prostatic radiation therapy on bladder contractility and innervation.
Neurourology and urodynamics 08, 2021 | Pubmed ID: 34015163
Ex vivo Akt inhibition reverses castration induced internal pudendal artery and penile endothelial dysfunction.
Life sciences Sep, 2021 | Pubmed ID: 34543641
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