Alexander K. Murashov
Department of Physiology
East Carolina University
Alexander Murashov is a Professor of Physiology at the Brody School of Medicine at East Carolina University, as well as a member of the East Carolina University Diabetes and Obesity Institute. He graduated from the 2nd Medical Institute Moscow, Russia, and received his doctorate in Physiology from the Anokhin Institute of Physiology, Russian Academy of Medical Sciences.
During Dr. Murashov’s training, he became fascinated by epigenetic mechanisms of the stress response. He was a Postdoctoral Scientist from 1992-1995 at Columbia University in the laboratory of Dr. Debra J. Wolgemuth, and Associate Research Scientist until 1999. Since then Dr. Murashov has served on the faculty of East Carolina University.
The research of Dr. Murashov focuses on regeneration of the mammalian nervous system, specifically on molecular mechanisms of axon growth. Recently, he has focused on the role miRNA plays in the epigenetics of transgenerational traits. Dr. Murashov was the first to show that exercise plays a role in transgenerational epigenetic programming of "thrifty phenotype."
17Beta-estradiol stimulates regeneration of sciatic nerve in female mice.
Brain research Jul, 2002 | Pubmed ID: 12101051
Development of the mouse vestibular system in the absence of gravity perception.
Brain research. Developmental brain research Jan, 2003 | Pubmed ID: 12524184
Effect of 17 beta-estradiol on gene expression in lumbar spinal cord following sciatic nerve crush injury in ovariectomized mice.
Brain research Mar, 2003 | Pubmed ID: 12646309
Differential expression of endothelin receptors in regenerating spinal motor neurons in mice.
Brain research. Molecular brain research Aug, 2003 | Pubmed ID: 12941473
Transplantation of neuronal and glial precursors dramatically improves sensorimotor function but not cognitive function in the traumatically injured brain.
Journal of neurotrauma Feb, 2004 | Pubmed ID: 15000757
Estrogen increases retrograde labeling of motoneurons: evidence of a nongenomic mechanism.
American journal of physiology. Cell physiology Aug, 2004 | Pubmed ID: 15044155
17beta-Estradiol enhances neuronal differentiation of mouse embryonic stem cells.
FEBS letters Jul, 2004 | Pubmed ID: 15225627
Induction of VEGF and its Flt-1 receptor after sciatic nerve crush injury.
Neuroreport Sep, 2004 | Pubmed ID: 15486493
Directed differentiation of embryonic stem cells into dorsal interneurons.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Feb, 2005 | Pubmed ID: 15545303
Parallel development of cardiomyocytes and neurons in embryonic stem cell culture.
Biochemical and biophysical research communications Jul, 2005 | Pubmed ID: 15894285
Predifferentiated embryonic stem cells prevent chronic pain behaviors and restore sensory function following spinal cord injury in mice.
Molecular medicine (Cambridge, Mass.) Jan-Mar, 2006 | Pubmed ID: 16838066
RNAi pathway is functional in peripheral nerve axons.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Mar, 2007 | Pubmed ID: 17209129
An animal model of oral dysphagia in amyotrophic lateral sclerosis.
Dysphagia Jun, 2009 | Pubmed ID: 19107538
Pre-differentiated embryonic stem cells promote neuronal regeneration by cross-coupling of BDNF and IL-6 signaling pathways in the host tissue.
Journal of neurotrauma Jul, 2009 | Pubmed ID: 19138107
Peripheral myelin protein 22 is regulated post-transcriptionally by miRNA-29a.
Glia Sep, 2009 | Pubmed ID: 19170179
A mouse model of pharyngeal dysphagia in amyotrophic lateral sclerosis.
Dysphagia Jun, 2010 | Pubmed ID: 19495873
A brief introduction to RNAi and microRNAs in stem cells.
Methods in molecular biology (Clifton, N.J.) , 2010 | Pubmed ID: 20686940
Monitoring microRNA expression during embryonic stem-cell differentiation using quantitative real-time PCR (qRT-PCR).
Methods in molecular biology (Clifton, N.J.) , 2010 | Pubmed ID: 20686954
Embryonic stem cells inhibit expression of erythropoietin in the injured spinal cord.
Neuroscience letters Jan, 2011 | Pubmed ID: 21056627
MicroRNA machinery responds to peripheral nerve lesion in an injury-regulated pattern.
Neuroscience Sep, 2011 | Pubmed ID: 21689732
Multi-walled carbon nanotubes inhibit regenerative axon growth of dorsal root ganglia neurons of mice.
Neuroscience letters Jan, 2012 | Pubmed ID: 22172934
Dicer-microRNA pathway is critical for peripheral nerve regeneration and functional recovery in vivo and regenerative axonogenesis in vitro.
Experimental neurology Jan, 2012 | Pubmed ID: 22178326
Molecular mechanisms of peripheral nerve regeneration: emerging roles of microRNAs.
Frontiers in physiology , 2013 | Pubmed ID: 23554595
MicroRNA-431 regulates axon regeneration in mature sensory neurons by targeting the Wnt antagonist Kremen1.
Frontiers in molecular neuroscience , 2013 | Pubmed ID: 24167472
Neurogenic potential of spinal cord organotypic culture.
Neuroscience letters May, 2015 | Pubmed ID: 25805458
Paternal long-term exercise programs offspring for low energy expenditure and increased risk for obesity in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology Feb, 2016 | Pubmed ID: 26506979
RNAi and MicroRNA-Mediated Gene Regulation in Stem Cells.
Methods in molecular biology (Clifton, N.J.) , 2017 | Pubmed ID: 28674798
Using Quantitative Real-Time PCR to Detect MicroRNA Expression Profile During Embryonic Stem Cell Differentiation.
Methods in molecular biology (Clifton, N.J.) , 2017 | Pubmed ID: 28674814
miRNA-431 Prevents Amyloid-β-Induced Synapse Loss in Neuronal Cell Culture Model of Alzheimer's Disease by Silencing Kremen1.
Frontiers in cellular neuroscience , 2018 | Pubmed ID: 29643768
Membrane Distribution and Activity of a Neuronal Voltage-Gated K+ Channel is Modified by Replacement of Complex Type N-Glycans with Hybrid Type.
Journal of glycobiology , 2017 | Pubmed ID: 30271698
CofActor: A light- and stress-gated optogenetic clustering tool to study disease-associated cytoskeletal dynamics in living cells.
The Journal of biological chemistry 08, 2020 | Pubmed ID: 32424038
Preference and detrimental effects of high fat, sugar, and salt diet in wild-caught Drosophila simulans are reversed by flight exercise.
FASEB bioAdvances Jan, 2021 | Pubmed ID: 33490883
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