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Department of Molecular Genetics,
The Donnelly Centre for Cellular and Biomolecular Research,
Department of Pharmacology and Toxicology
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The forkhead transcription factor UNC-130 is required for the graded spatial expression of the UNC-129 TGF-beta guidance factor in C. elegans.
Genes & development Oct, 2000 | Pubmed ID: 11018016
Muscle arm development in Caenorhabditis elegans.
Development (Cambridge, England) Jul, 2005 | Pubmed ID: 15930100
Network news: functional modules revealed during early embryogenesis in C. elegans.
Developmental cell Sep, 2005 | Pubmed ID: 16139218
FGF negatively regulates muscle membrane extension in Caenorhabditis elegans.
Development (Cambridge, England) Apr, 2006 | Pubmed ID: 16495308
A small-molecule screen in C. elegans yields a new calcium channel antagonist.
Nature May, 2006 | Pubmed ID: 16672971
High-throughput screening of small molecules for bioactivity and target identification in Caenorhabditis elegans.
Nature protocols , 2006 | Pubmed ID: 17487175
Cell-specific microarray profiling experiments reveal a comprehensive picture of gene expression in the C. elegans nervous system.
Genome biology , 2007 | Pubmed ID: 17612406
A global analysis of genetic interactions in Caenorhabditis elegans.
Journal of biology , 2007 | Pubmed ID: 17897480
Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen.
PLoS genetics Feb, 2008 | Pubmed ID: 18454192
A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans.
Nature chemical biology Jul, 2010 | Pubmed ID: 20512140
MADD-2, a homolog of the Opitz syndrome protein MID1, regulates guidance to the midline through UNC-40 in Caenorhabditis elegans.
Developmental cell Jun, 2010 | Pubmed ID: 20627078
MADD-4 is a secreted cue required for midline-oriented guidance in Caenorhabditis elegans.
Developmental cell Oct, 2011 | Pubmed ID: 22014523
Compound prioritization methods increase rates of chemical probe discovery in model organisms.
Chemistry & biology Oct, 2011 | Pubmed ID: 22035796
Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans.
Nature chemical biology Dec, 2011 | Pubmed ID: 22057127
Orthosteric and allosteric drug binding sites in the Caenorhabditis elegans mgl-2 metabotropic glutamate receptor.
Neuropharmacology Sep, 2012 | Pubmed ID: 22652059
EVA-1 functions as an UNC-40 Co-receptor to enhance attraction to the MADD-4 guidance cue in Caenorhabditis elegans.
PLoS genetics Aug, 2014 | Pubmed ID: 25122090
Caenorhabditis elegans is a useful model for anthelmintic discovery.
Nature communications Jun, 2015 | Pubmed ID: 26108372
The MADD-3 LAMMER Kinase Interacts with a p38 MAP Kinase Pathway to Regulate the Display of the EVA-1 Guidance Receptor in Caenorhabditis elegans.
PLoS genetics 04, 2016 | Pubmed ID: 27123983
The novel nematicide wact-86 interacts with aldicarb to kill nematodes.
PLoS neglected tropical diseases 04, 2017 | Pubmed ID: 28379972
The marginal cells of the Caenorhabditis elegans pharynx scavenge cholesterol and other hydrophobic small molecules.
Nature communications 09, 2019 | Pubmed ID: 31477732
Author Correction: Caenorhabditis elegans is a useful model for anthelmintic discovery.
Nature communications 07, 2020 | Pubmed ID: 32709866
A survey of the kinome pharmacopeia reveals multiple scaffolds and targets for the development of novel anthelmintics.
Scientific reports 04, 2021 | Pubmed ID: 33911106
University of Toronto
Savina R. Cammalleri1,2,3,
Jessica Knox1,3,
Peter J. Roy1,3,4
1Department of Molecular Genetics, University of Toronto,
2Department of Biochemistry, University of Toronto,
3The Donnelly Centre for Cellular and Biomolecular Research, University of Toronto,
4Department of Pharmacology and Toxicology, University of Toronto
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