Scott J. Snipas

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.

Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes.

Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families.

SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth.

Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1.

Caspase selective reagents for diagnosing apoptotic mechanisms.

Selective Substrates and Activity-Based Probes for Imaging of the Human Constitutive 20S Proteasome in Cells and Blood Samples.

Determination of extended substrate specificity of the MALT1 as a strategy for the design of potent substrates and activity-based probes.

Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells.

Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells.

Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation.

Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide.

Detection of Active Granzyme A in NK92 Cells with Fluorescent Activity-Based Probe.

Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy.

Noninvasive optical detection of granzyme B from natural killer cells with enzyme-activated fluorogenic probes.

Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11.

Engineering caspase 7 as an affinity reagent to capture proteolytic products.

Multiplexed Probing of Proteolytic Enzymes Using Mass Cytometry-Compatible Activity-Based Probes.

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes.

Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design.

NETosis occurs independently of neutrophil serine proteases.

Evaluation of the effects of phosphorylation of synthetic peptide substrates on their cleavage by caspase-3 and -7.

Resurrection of an ancient inflammatory locus reveals switch to caspase-1 specificity on a caspase-4 scaffold.

Gain of function of a metalloproteinase associated with multiple myeloma, bicuspid aortic valve, and Von Hippel-Lindau syndrome.