Department of Pathology
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Three classes of genes mutated in colorectal cancers with chromosomal instability.
Cancer research May, 2004 | Pubmed ID: 15126332
Patterns of p53 mutations separate ovarian serous borderline tumors and low- and high-grade carcinomas and provide support for a new model of ovarian carcinogenesis: a mutational analysis with immunohistochemical correlation.
The American journal of surgical pathology Feb, 2005 | Pubmed ID: 15644779
Activation of mitogen-activated protein kinase is required for migration and invasion of placental site trophoblastic tumor.
The American journal of pathology Sep, 2005 | Pubmed ID: 16127165
Amplification of a chromatin remodeling gene, Rsf-1/HBXAP, in ovarian carcinoma.
Proceedings of the National Academy of Sciences of the United States of America Sep, 2005 | Pubmed ID: 16172393
Digital karyotyping: an update of its applications in cancer.
Molecular diagnosis & therapy , 2006 | Pubmed ID: 16884326
Analysis of DNA copy number alterations in ovarian serous tumors identifies new molecular genetic changes in low-grade and high-grade carcinomas.
Cancer research May, 2009 | Pubmed ID: 19383911
Utility of p16 expression for distinction of uterine serous carcinomas from endometrial endometrioid and endocervical adenocarcinomas: immunohistochemical analysis of 201 cases.
The American journal of surgical pathology Oct, 2009 | Pubmed ID: 19623034
DNA copy numbers profiles in affinity-purified ovarian clear cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research Apr, 2010 | Pubmed ID: 20233889
Distinct DNA methylation profiles in ovarian serous neoplasms and their implications in ovarian carcinogenesis.
American journal of obstetrics and gynecology Dec, 2010 | Pubmed ID: 20965493
Mutation and loss of expression of ARID1A in uterine low-grade endometrioid carcinoma.
The American journal of surgical pathology May, 2011 | Pubmed ID: 21412130
Mutation of PPP2R1A: a new clue in unveiling the pathogenesis of uterine serous carcinoma.
The Journal of pathology May, 2011 | Pubmed ID: 21432855
Molecular genetic markers in female reproductive cancers.
Journal of oncology , 2010 | Pubmed ID: 21541207
ARID1A, a factor that promotes formation of SWI/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancers.
Cancer research Nov, 2011 | Pubmed ID: 21900401
Mapping DNA Quantity into Electrophoretic Mobility through Quantum Dot Nanotethers for High-Resolution Genetic and Epigenetic Analysis.
ACS nano Jan, 2012 | Pubmed ID: 22136600
Functional analysis of in-frame indel ARID1A mutations reveals new regulatory mechanisms of its tumor suppressor functions.
Neoplasia (New York, N.Y.) Oct, 2012 | Pubmed ID: 23097632
High level of chromosomal aberration in ovarian cancer genome correlates with poor clinical outcome.
Gynecologic oncology Mar, 2013 | Pubmed ID: 23200914
The role of forkhead box Q1 transcription factor in ovarian epithelial carcinomas.
International journal of molecular sciences Oct, 2012 | Pubmed ID: 23203039
TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2013 | Pubmed ID: 23530248
Establishing isogenic inducible cell lines using founder reporter lines and recombinase-mediated cassette exchange.
BioTechniques Nov, 2013 | Pubmed ID: 24215638
The emerging roles of ARID1A in tumor suppression.
Cancer biology & therapy Jun, 2014 | Pubmed ID: 24618703
Roles of deletion of Arid1a, a tumor suppressor, in mouse ovarian tumorigenesis.
Journal of the National Cancer Institute Jul, 2014 | Pubmed ID: 24899687
Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer.
PLoS genetics Oct, 2014 | Pubmed ID: 25356737
Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules.
Cancer cell Jul, 2015 | Pubmed ID: 26096845
Mevalonate Pathway Antagonist Suppresses Formation of Serous Tubal Intraepithelial Carcinoma and Ovarian Carcinoma in Mouse Models.
Clinical cancer research : an official journal of the American Association for Cancer Research Oct, 2015 | Pubmed ID: 26109099
Inactivating ARID1A Tumor Suppressor Enhances TERT Transcription and Maintains Telomere Length in Cancer Cells.
The Journal of biological chemistry Apr, 2016 | Pubmed ID: 26953344
Yes-associated protein impacts adherens junction assembly through regulating actin cytoskeleton organization.
American journal of physiology. Gastrointestinal and liver physiology Sep, 2016 | Pubmed ID: 27229120
PD-L1 Expression in Human Placentas and Gestational Trophoblastic Diseases.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists Mar, 2017 | Pubmed ID: 27362903
Ovarian Cancer Chemoresistance Relies on the Stem Cell Reprogramming Factor PBX1.
Cancer research Nov, 2016 | Pubmed ID: 27590741
Human transposon insertion profiling: Analysis, visualization and identification of somatic LINE-1 insertions in ovarian cancer.
Proceedings of the National Academy of Sciences of the United States of America Jan, 2017 | Pubmed ID: 28096347
Mutation of NRAS is a rare genetic event in ovarian low-grade serous carcinoma.
Human pathology Oct, 2017 | Pubmed ID: 28873354
High grade serous ovarian carcinomas originate in the fallopian tube.
Nature communications Oct, 2017 | Pubmed ID: 29061967
Detection and localization of surgically resectable cancers with a multi-analyte blood test.
Science (New York, N.Y.) Feb, 2018 | Pubmed ID: 29348365
Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers.
Science translational medicine Mar, 2018 | Pubmed ID: 29563323
Inhibition of ovarian tumor cell invasiveness by targeting SYK in the tyrosine kinase signaling pathway.
Oncogene Jul, 2018 | Pubmed ID: 29643476
Methylomic Analysis of Ovarian Cancers Identifies Tumor-Specific Alterations Readily Detectable in Early Precursor Lesions.
Clinical cancer research : an official journal of the American Association for Cancer Research Dec, 2018 | Pubmed ID: 30108103
Fallopian Tube Lesions in Women at High Risk for Ovarian Cancer: A Multicenter Study.
Cancer prevention research (Philadelphia, Pa.) Nov, 2018 | Pubmed ID: 30232083
PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8 T-cell Function.
Cancer immunology research Feb, 2019 | Pubmed ID: 30659054
Molecular Classification and Emerging Targeted Therapy in Endometrial Cancer.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists Jan, 2020 | Pubmed ID: 30741844
Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment.
Nature communications Feb, 2019 | Pubmed ID: 30760718
Cytomorphologic and molecular analyses of fallopian tube fimbrial brushings for diagnosis of serous tubal intraepithelial carcinoma.
Cancer cytopathology Mar, 2019 | Pubmed ID: 30861338
Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer.
Cell reports Apr, 2019 | Pubmed ID: 30970252
Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research Sep, 2019 | Pubmed ID: 31196855
Clinicopathologic and Molecular Features of Paired Cases of Metachronous Ovarian Serous Borderline Tumor and Subsequent Serous Carcinoma.
The American journal of surgical pathology Nov, 2019 | Pubmed ID: 31343420
Spleen tyrosine kinase activity regulates epidermal growth factor receptor signaling pathway in ovarian cancer.
EBioMedicine Sep, 2019 | Pubmed ID: 31492560
-mutated ovarian serous borderline tumors are at relatively low risk for progression to serous carcinoma.
Oncotarget Dec, 2019 | Pubmed ID: 31839880
Epithelial Cells in Endometriosis and Adenomyosis Upregulate STING Expression.
Reproductive sciences (Thousand Oaks, Calif.) Jun, 2020 | Pubmed ID: 32046461
Assessing aneuploidy with repetitive element sequencing.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2020 | Pubmed ID: 32075918
Inactivation of Arid1a in the endometrium is associated with endometrioid tumorigenesis through transcriptional reprogramming.
Nature communications Jun, 2020 | Pubmed ID: 32483112
Methylomic Landscapes of Ovarian Cancer Precursor Lesions.
Clinical cancer research : an official journal of the American Association for Cancer Research Dec, 2020 | Pubmed ID: 32817081
Inhibition of the MYC-Regulated Glutaminase Metabolic Axis Is an Effective Synthetic Lethal Approach for Treating Chemoresistant Ovarian Cancers.
Cancer research Oct, 2020 | Pubmed ID: 32859605
The Origin of Ovarian Cancer Species and Precancerous Landscape.
The American journal of pathology Jan, 2021 | Pubmed ID: 33011111
Correction: -mutated ovarian serous borderline tumors are at relatively low risk for progression to serous carcinoma.
Oncotarget Jun, 2021 | Pubmed ID: 34194631
A novel human endometrial epithelial cell line for modeling gynecological diseases and for drug screening.
Laboratory investigation; a journal of technical methods and pathology Nov, 2021 | Pubmed ID: 34376780
Mutation and methylation profiles of ectopic and eutopic endometrial tissues.
The Journal of pathology Dec, 2021 | Pubmed ID: 34396532
Development of small molecule inhibitors targeting PBX1 transcription signaling as a novel cancer therapeutic strategy.
iScience Nov, 2021 | Pubmed ID: 34816098
Systems medicine dissection of chr1q-amp reveals a novel PBX1-FOXM1 axis for targeted therapy in multiple myeloma.
Blood Mar, 2022 | Pubmed ID: 35015835
Current and Emerging Methods for Ovarian Cancer Screening and Diagnostics: A Comprehensive Review.
Cancers Jun, 2022 | Pubmed ID: 35740550
Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response.
Journal of biomedical science Sep, 2022 | Pubmed ID: 36123603
Targeting glutamine metabolism enhances responses to platinum-based chemotherapy in triple-negative breast cancers (TNBC).
Genes & diseases Nov, 2022 | Pubmed ID: 36157486
Spatial Transcriptomic Analysis of Ovarian Cancer Precursors Reveals Reactivation of IGFBP2 during Pathogenesis.
Cancer research Dec, 2022 | Pubmed ID: 36206311
Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker.
bioRxiv : the preprint server for biology Jan, 2023 | Pubmed ID: 36747644
A novel human endometrial epithelial cell line for modeling gynecological diseases and for drug screening.
Laboratory investigation; a journal of technical methods and pathology Nov, 2021 | Pubmed ID: 36775477
Rachel Vistein1,
Briana Winer2,
Stephanie Myers1,3,
Juliane Liberto4,
Shun Ishiyama1,5,6,
Xin Guo1,
Harumi Saeki7,
Tian-Li Wang4,8,
Ie-Ming Shih2,4,8,
Kathleen Gabrielson1,4,8
1Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine,
2Department of Obstetrics and Gynecology, Johns Hopkins University School of Medicine,
3, Texas Tech University School of Veterinary Medicine,
4Department of Pathology, Johns Hopkins University School of Medicine,
5Department of Surgery, Johns Hopkins University School of Medicine,
6Department of Coloproctological Surgery, Juntendo University School of Medicine,
7Department of Human Pathology, Juntendo University School of Medicine,
8Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University