Department of Microbiology,
Penn Center for Research on Coronaviruses and Other Emerging Pathogens,
Perelman School of Medicine,
Penn Center for Research on Coronaviruses and Other Emerging Pathogens, Perelman School of Medicine
i have been wroking on coronavirus replication and pathogenesis for forty years.
Intracellular processing of the N-terminal ORF 1a proteins of the coronavirus MHV-A59 requires multiple proteolytic events.
Virology Jul, 1992 | Pubmed ID: 1318604
Mouse hepatitis virus A59 increases steady-state levels of MHC mRNAs in primary glial cell cultures and in the murine central nervous system.
Microbial pathogenesis Dec, 1992 | Pubmed ID: 1338798
Mouse hepatitis virus ORF 2a is expressed in the cytosol of infected mouse fibroblasts.
Virology Feb, 1990 | Pubmed ID: 2154893
Induction of MHC class I antigens on glial cells is dependent on persistent mouse hepatitis virus infection.
Journal of neuroimmunology Apr, 1989 | Pubmed ID: 2538490
Molecular cloning of the gene encoding the putative polymerase of mouse hepatitis coronavirus, strain A59.
Virology Jul, 1989 | Pubmed ID: 2545027
A general method for the induction and screening of antisera for cDNA-encoded polypeptides: antibodies specific for a coronavirus putative polymerase-encoding gene.
Gene Dec, 1989 | Pubmed ID: 2560756
Detection of a murine coronavirus nonstructural protein encoded in a downstream open reading frame.
Virology May, 1988 | Pubmed ID: 2834866
Coronavirus mouse hepatitis virus (MHV)-A59 causes a persistent, productive infection in primary glial cell cultures.
Microbial pathogenesis Aug, 1987 | Pubmed ID: 2849019
In vitro synthesis of two polypeptides from a nonstructural gene of coronavirus mouse hepatitis virus strain A59.
Virology Apr, 1987 | Pubmed ID: 3029985
Coronaviruses SD and SK share extensive nucleotide homology with murine coronavirus MHV-A59, more than that shared between human and murine coronaviruses.
Virology Apr, 1983 | Pubmed ID: 6687965
Mouse hepatitis virus A59-induced demyelination can occur in the absence of CD8+ T cells.
Microbial pathogenesis Mar, 1995 | Pubmed ID: 7565015
Identification and characterization of a 65-kDa protein processed from the gene 1 polyprotein of the murine coronavirus MHV-A59.
Virology Feb, 1995 | Pubmed ID: 7871746
Mouse hepatitis virus strain A59 RNA polymerase gene ORF 1a: heterogeneity among MHV strains.
Virology Feb, 1994 | Pubmed ID: 8291254
The ns 4 gene of mouse hepatitis virus (MHV), strain A 59 contains two ORFs and thus differs from ns 4 of the JHM and S strains.
Archives of virology , 1993 | Pubmed ID: 8385918
Syncytia formation induced by coronavirus infection is associated with fragmentation and rearrangement of the Golgi apparatus.
Virology Jul, 1996 | Pubmed ID: 8661443
Efficient autoproteolytic processing of the MHV-A59 3C-like proteinase from the flanking hydrophobic domains requires membranes.
Virology Apr, 1997 | Pubmed ID: 9143287
Altered pathogenesis of a mutant of the murine coronavirus MHV-A59 is associated with a Q159L amino acid substitution in the spike protein.
Virology Dec, 1997 | Pubmed ID: 9426441
The spike protein of murine coronavirus mouse hepatitis virus strain A59 is not cleaved in primary glial cells and primary hepatocytes.
Journal of virology Feb, 1998 | Pubmed ID: 9445064
Roles in cell-to-cell fusion of two conserved hydrophobic regions in the murine coronavirus spike protein.
Virology May, 1998 | Pubmed ID: 9601516
Targeted recombination within the spike gene of murine coronavirus mouse hepatitis virus-A59: Q159 is a determinant of hepatotropism.
Journal of virology Dec, 1998 | Pubmed ID: 9811696
Cellular reservoirs for coronavirus infection of the brain in beta2-microglobulin knockout mice.
Pathobiology : journal of immunopathology, molecular and cellular biology , 1999 | Pubmed ID: 10023135
Expression of murine coronavirus recombinant papain-like proteinase: efficient cleavage is dependent on the lengths of both the substrate and the proteinase polypeptides.
Journal of virology Apr, 1999 | Pubmed ID: 10074111
Pathogenesis of chimeric MHV4/MHV-A59 recombinant viruses: the murine coronavirus spike protein is a major determinant of neurovirulence.
Journal of virology Sep, 1999 | Pubmed ID: 10438865
Amino acid substitutions within the leucine zipper domain of the murine coronavirus spike protein cause defects in oligomerization and the ability to induce cell-to-cell fusion.
Journal of virology Oct, 1999 | Pubmed ID: 10482565
Further requirements for cleavage by the murine coronavirus 3C-like proteinase: identification of a cleavage site within ORF1b.
Virology Oct, 1999 | Pubmed ID: 10544119
Demyelination determinants map to the spike glycoprotein gene of coronavirus mouse hepatitis virus.
Journal of virology Oct, 2000 | Pubmed ID: 10982367
Murine coronavirus spike protein determines the ability of the virus to replicate in the liver and cause hepatitis.
Journal of virology Mar, 2001 | Pubmed ID: 11160748
Multiple regions of the murine coronavirus spike glycoprotein influence neurovirulence.
Journal of neurovirology Oct, 2001 | Pubmed ID: 11582514
Further in vitro characterization of mouse hepatitis virus papain-like proteinase 1: cleavage sequence requirements within pp1a.
Journal of neurovirology Apr, 2002 | Pubmed ID: 11935466
Murine coronavirus spike glycoprotein mediates degree of viral spread, inflammation, and virus-induced immunopathology in the central nervous system.
Virology Sep, 2002 | Pubmed ID: 12359451
Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59.
Journal of virology Nov, 2002 | Pubmed ID: 12368349
Perforin-mediated CTL cytolysis counteracts direct cell-cell spread of Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950) Nov, 2002 | Pubmed ID: 12391238
Enhanced green fluorescent protein expression may be used to monitor murine coronavirus spread in vitro and in the mouse central nervous system.
Journal of neurovirology Oct, 2002 | Pubmed ID: 12402164
The virulence of mouse hepatitis virus strain A59 is not dependent on efficient spike protein cleavage and cell-to-cell fusion.
Journal of neurovirology Oct, 2002 | Pubmed ID: 12402166
Conformational changes in the spike glycoprotein of murine coronavirus are induced at 37 degrees C either by soluble murine CEACAM1 receptors or by pH 8.
Journal of virology Jan, 2003 | Pubmed ID: 12502799
The N-terminal domain of the murine coronavirus spike glycoprotein determines the CEACAM1 receptor specificity of the virus strain.
Journal of virology Jan, 2003 | Pubmed ID: 12502800
Murine coronavirus-induced hepatitis: JHM genetic background eliminates A59 spike-determined hepatotropism.
Journal of virology Apr, 2003 | Pubmed ID: 12663803
Amino acid substitutions within the heptad repeat domain 1 of murine coronavirus spike protein restrict viral antigen spread in the central nervous system.
Virology Aug, 2003 | Pubmed ID: 12919742
The glycosylation status of the murine hepatitis coronavirus M protein affects the interferogenic capacity of the virus in vitro and its ability to replicate in the liver but not the brain.
Virology Aug, 2003 | Pubmed ID: 12919744
Effects of an epitope-specific CD8+ T-cell response on murine coronavirus central nervous system disease: protection from virus replication and antigen spread and selection of epitope escape mutants.
Journal of virology Feb, 2004 | Pubmed ID: 14722270
SARS: lessons learned from other coronaviruses.
Viral immunology , 2003 | Pubmed ID: 14733734
Coronavirus replication and pathogenesis: Implications for the recent outbreak of severe acute respiratory syndrome (SARS), and the challenge for vaccine development.
Journal of neurovirology Apr, 2004 | Pubmed ID: 15204926
Increased epitope-specific CD8+ T cells prevent murine coronavirus spread to the spinal cord and subsequent demyelination.
Journal of virology Mar, 2005 | Pubmed ID: 15731231
Single-amino-acid substitutions in open reading frame (ORF) 1b-nsp14 and ORF 2a proteins of the coronavirus mouse hepatitis virus are attenuating in mice.
Journal of virology Mar, 2005 | Pubmed ID: 15731233
Identification of murine CD8 T cell epitopes in codon-optimized SARS-associated coronavirus spike protein.
Virology Apr, 2005 | Pubmed ID: 15823604
Murine coronavirus evolution in vivo: functional compensation of a detrimental amino acid substitution in the receptor binding domain of the spike glycoprotein.
Journal of virology Jun, 2005 | Pubmed ID: 15919915
Expression and purification of SARS coronavirus proteins using SUMO-fusions.
Protein expression and purification Jul, 2005 | Pubmed ID: 15939295
Contributions of the viral genetic background and a single amino acid substitution in an immunodominant CD8+ T-cell epitope to murine coronavirus neurovirulence.
Journal of virology Jul, 2005 | Pubmed ID: 15994805
Enhanced expression and purification of membrane proteins by SUMO fusion in Escherichia coli.
Journal of structural and functional genomics , 2005 | Pubmed ID: 16211506
Expression of hemagglutinin esterase protein from recombinant mouse hepatitis virus enhances neurovirulence.
Journal of virology Dec, 2005 | Pubmed ID: 16306577
Coronavirus pathogenesis and the emerging pathogen severe acute respiratory syndrome coronavirus.
Microbiology and molecular biology reviews : MMBR Dec, 2005 | Pubmed ID: 16339739
Endosomal proteolysis by cathepsins is necessary for murine coronavirus mouse hepatitis virus type 2 spike-mediated entry.
Journal of virology Jun, 2006 | Pubmed ID: 16731916
Both spike and background genes contribute to murine coronavirus neurovirulence.
Journal of virology Jul, 2006 | Pubmed ID: 16809289
CD8+ T-cell priming during a central nervous system infection with mouse hepatitis virus.
Advances in experimental medicine and biology , 2006 | Pubmed ID: 17037564
Murine hepatitis virus strain 1 produces a clinically relevant model of severe acute respiratory syndrome in A/J mice.
Journal of virology Nov, 2006 | Pubmed ID: 17041219
Replicase genes of murine coronavirus strains A59 and JHM are interchangeable: differences in pathogenesis map to the 3' one-third of the genome.
Journal of virology Jan, 2007 | Pubmed ID: 17079303
Inhibition of the alpha/beta interferon response by mouse hepatitis virus at multiple levels.
Journal of virology Jul, 2007 | Pubmed ID: 17459917
The spike glycoprotein of murine coronavirus MHV-JHM mediates receptor-independent infection and spread in the central nervous systems of Ceacam1a-/- Mice.
Journal of virology Jan, 2008 | Pubmed ID: 18003729
The SARS-CoV ferret model in an infection-challenge study.
Virology Apr, 2008 | Pubmed ID: 18234270
Chemokine expression during mouse-hepatitis-virus-induced encephalitis: contributions of the spike and background genes.
Journal of neurovirology Jan, 2008 | Pubmed ID: 18300071
Demyelinating and nondemyelinating strains of mouse hepatitis virus differ in their neural cell tropism.
Journal of virology Jun, 2008 | Pubmed ID: 18385249
Priming of CD8+ T cells during central nervous system infection with a murine coronavirus is strain dependent.
Journal of virology Jul, 2008 | Pubmed ID: 18417581
Murine coronavirus mouse hepatitis virus is recognized by MDA5 and induces type I interferon in brain macrophages/microglia.
Journal of virology Oct, 2008 | Pubmed ID: 18667505
Organ-specific attenuation of murine hepatitis virus strain A59 by replacement of catalytic residues in the putative viral cyclic phosphodiesterase ns2.
Journal of virology Apr, 2009 | Pubmed ID: 19176619
The murine coronavirus nucleocapsid gene is a determinant of virulence.
Journal of virology Feb, 2010 | Pubmed ID: 20007284
Murine Coronavirus Cell Type Dependent Interaction with the Type I Interferon Response.
Viruses Dec, 2009 | Pubmed ID: 20221421
Murine coronavirus delays expression of a subset of interferon-stimulated genes.
Journal of virology Jun, 2010 | Pubmed ID: 20357099
Pathogenesis of murine coronavirus in the central nervous system.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology Sep, 2010 | Pubmed ID: 20369302
Genetic determinants of mouse hepatitis virus strain 1 pneumovirulence.
Journal of virology Sep, 2010 | Pubmed ID: 20631137
Murine coronavirus receptors are differentially expressed in the central nervous system and play virus strain-dependent roles in neuronal spread.
Journal of virology Nov, 2010 | Pubmed ID: 20739537
Murine coronavirus neuropathogenesis: determinants of virulence.
Journal of neurovirology Nov, 2010 | Pubmed ID: 21073281
Pathogenesis of neurotropic murine coronavirus is multifactorial.
Trends in pharmacological sciences Jan, 2011 | Pubmed ID: 21144598
Characteristics of opioid prescriptions in 2009.
JAMA Apr, 2011 | Pubmed ID: 21467282
Cell-type-specific type I interferon antagonism influences organ tropism of murine coronavirus.
Journal of virology Oct, 2011 | Pubmed ID: 21752905
The role of interferon antagonist, non-structural proteins in the pathogenesis and emergence of arboviruses.
Viruses Jun, 2011 | Pubmed ID: 21994750
Coronavirus pathogenesis.
Advances in virus research , 2011 | Pubmed ID: 22094080
A novel full-length isoform of murine pregnancy-specific glycoprotein 16 (psg16) is expressed in the brain but does not mediate murine coronavirus (MHV) entry.
Journal of neurovirology Apr, 2012 | Pubmed ID: 22302612
Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology.
Cell host & microbe Jun, 2012 | Pubmed ID: 22704621
Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms.
Journal of virology Jul, 2013 | Pubmed ID: 23678171
Cell-type-specific activation of the oligoadenylate synthetase-RNase L pathway by a murine coronavirus.
Journal of virology Aug, 2013 | Pubmed ID: 23698313
Homologous 2',5'-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity.
Proceedings of the National Academy of Sciences of the United States of America Aug, 2013 | Pubmed ID: 23878220
Analysis of the host transcriptome from demyelinating spinal cord of murine coronavirus-infected mice.
PloS one , 2013 | Pubmed ID: 24058676
Cell-type-specific effects of RNase L on viral induction of beta interferon.
mBio Feb, 2014 | Pubmed ID: 24570368
Evaluation of SSYA10-001 as a replication inhibitor of severe acute respiratory syndrome, mouse hepatitis, and Middle East respiratory syndrome coronaviruses.
Antimicrobial agents and chemotherapy Aug, 2014 | Pubmed ID: 24841268
Viral phosphodiesterases that antagonize double-stranded RNA signaling to RNase L by degrading 2-5A.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research Jun, 2014 | Pubmed ID: 24905202
Murine AKAP7 has a 2',5'-phosphodiesterase domain that can complement an inactive murine coronavirus ns2 gene.
mBio Jul, 2014 | Pubmed ID: 24987090
Coronavirus-induced demyelination of neural pathways triggers neurogenic bladder overactivity in a mouse model of multiple sclerosis.
American journal of physiology. Renal physiology Sep, 2014 | Pubmed ID: 25007876
The nsp1, nsp13, and M proteins contribute to the hepatotropism of murine coronavirus JHM.WU.
Journal of virology Apr, 2015 | Pubmed ID: 25589656
Structural basis for 2'-5'-oligoadenylate binding and enzyme activity of a viral RNase L antagonist.
Journal of virology Jul, 2015 | Pubmed ID: 25878106
MDA5 Is Critical to Host Defense during Infection with Murine Coronavirus.
Journal of virology Dec, 2015 | Pubmed ID: 26423942
RNase L is a negative regulator of cell migration.
Oncotarget Dec, 2015 | Pubmed ID: 26517238
Activation of RNase L by Murine Coronavirus in Myeloid Cells Is Dependent on Basal Oas Gene Expression and Independent of Virus-Induced Interferon.
Journal of virology Jan, 2016 | Pubmed ID: 26739051
Crystal structure of the mouse hepatitis virus ns2 phosphodiesterase domain that antagonizes RNase L activation.
The Journal of general virology Apr, 2016 | Pubmed ID: 26757803
Primary Role for Toll-Like Receptor-Driven Tumor Necrosis Factor Rather than Cytosolic Immune Detection in Restricting Coxiella burnetii Phase II Replication within Mouse Macrophages.
Infection and immunity Apr, 2016 | Pubmed ID: 26787725
Activation of RNase L is dependent on OAS3 expression during infection with diverse human viruses.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2016 | Pubmed ID: 26858407
Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation.
mBio Mar, 2016 | Pubmed ID: 27025250
Antagonism of RNase L Is Required for Murine Coronavirus Replication in Kupffer Cells and Liver Sinusoidal Endothelial Cells but Not in Hepatocytes.
Journal of virology Nov, 2016 | Pubmed ID: 27558415
Lineage A Betacoronavirus NS2 Proteins and the Homologous Torovirus Berne pp1a Carboxy-Terminal Domain Are Phosphodiesterases That Antagonize Activation of RNase L.
Journal of virology Mar, 2017 | Pubmed ID: 28003490
Neurovirulent Murine Coronavirus JHM.SD Uses Cellular Zinc Metalloproteases for Virus Entry and Cell-Cell Fusion.
Journal of virology Apr, 2017 | Pubmed ID: 28148786
Early endonuclease-mediated evasion of RNA sensing ensures efficient coronavirus replication.
PLoS pathogens Feb, 2017 | Pubmed ID: 28158275
Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line.
eLife Mar, 2017 | Pubmed ID: 28362255
Role of the inflammasome-related cytokines Il-1 and Il-18 during infection with murine coronavirus.
Journal of neurovirology Dec, 2017 | Pubmed ID: 28895072
Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence.
Nature communications Oct, 2017 | Pubmed ID: 28986577
Origins and pathogenesis of Middle East respiratory syndrome-associated coronavirus: recent advances.
F1000Research , 2017 | Pubmed ID: 29026532
Murine Hepatitis Virus nsp14 Exoribonuclease Activity Is Required for Resistance to Innate Immunity.
Journal of virology Jan, 2018 | Pubmed ID: 29046453
A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L.
PLoS pathogens Apr, 2018 | Pubmed ID: 29652922
Third Tofo Advanced Study Week on Emerging and Re-emerging Viruses, 2018.
Antiviral research Feb, 2019 | Pubmed ID: 30597184
Real-time 2-5A kinetics suggest that interferons β and λ evade global arrest of translation by RNase L.
Proceedings of the National Academy of Sciences of the United States of America Feb, 2019 | Pubmed ID: 30655338
OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug.
Proceedings of the National Academy of Sciences of the United States of America Mar, 2019 | Pubmed ID: 30814222
Antagonism of dsRNA-Induced Innate Immune Pathways by NS4a and NS4b Accessory Proteins during MERS Coronavirus Infection.
mBio Mar, 2019 | Pubmed ID: 30914508
Zika Virus Production Is Resistant to RNase L Antiviral Activity.
Journal of virology Aug, 2019 | Pubmed ID: 31142667
Activation of RNase L in Egyptian Rousette Bat-Derived RoNi/7 Cells Is Dependent Primarily on OAS3 and Independent of MAVS Signaling.
mBio Nov, 2019 | Pubmed ID: 31719180
No credible evidence supporting claims of the laboratory engineering of SARS-CoV-2.
Emerging microbes & infections , 2020 | Pubmed ID: 32102621
Forty years with coronaviruses.
The Journal of experimental medicine May, 2020 | Pubmed ID: 32232339
Broad Anti-coronavirus Activity of Food and Drug Administration-Approved Drugs against SARS-CoV-2 and SARS-CoV .
Journal of virology Oct, 2020 | Pubmed ID: 32817221
A phenolic small molecule inhibitor of RNase L prevents cell death from ADAR1 deficiency.
Proceedings of the National Academy of Sciences of the United States of America Oct, 2020 | Pubmed ID: 32958664
Physiologic RNA targets and refined sequence specificity of coronavirus EndoU.
RNA (New York, N.Y.) Dec, 2020 | Pubmed ID: 32989044
SARS-CoV-2 Genomic Variation in Space and Time in Hospitalized Patients in Philadelphia.
mBio Jan, 2021 | Pubmed ID: 33468702
Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape.
Nature communications Jan, 2021 | Pubmed ID: 33473140
Copan eNAT Transport System To Address Challenges in COVID-19 Diagnostics in Regions with Limited Testing Access.
Journal of clinical microbiology Apr, 2021 | Pubmed ID: 33579730
Activation of STING Signaling Pathway Effectively Blocks Human Coronavirus Infection.
Journal of virology May, 2021 | Pubmed ID: 33789998
Femtomolar SARS-CoV-2 Antigen Detection Using the Microbubbling Digital Assay with Smartphone Readout Enables Antigen Burden Quantitation and Dynamics Tracking.
medRxiv : the preprint server for health sciences Mar, 2021 | Pubmed ID: 33791710
SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes.
Proceedings of the National Academy of Sciences of the United States of America 04, 2021 | Pubmed ID: 33811184
Discrimination of SARS-CoV-2 infected patient samples by detection dogs: A proof of concept study.
PloS one , 2021 | Pubmed ID: 33852639
Zika virus employs the host antiviral RNase L protein to support replication factory assembly.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2021 | Pubmed ID: 34031250
Detection of SARS-CoV-2 RNA using RT-LAMP and molecular beacons.
Genome biology Jun, 2021 | Pubmed ID: 34082799
Author Correction: Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape.
Nature communications Jul, 2021 | Pubmed ID: 34210985
Femtomolar SARS-CoV-2 Antigen Detection Using the Microbubbling Digital Assay with Smartphone Readout Enables Antigen Burden Quantitation and Tracking.
Clinical chemistry Dec, 2021 | Pubmed ID: 34383886
Multiplexed detection of SARS-CoV-2 genomic and subgenomic RNA using hybridization.
bioRxiv : the preprint server for biology Aug, 2021 | Pubmed ID: 34401878
The origins of SARS-CoV-2: A critical review.
Cell Sep, 2021 | Pubmed ID: 34480864
Single- and Two-Stage, Closed-Tube, Point-of-Care, Molecular Detection of SARS-CoV-2.
Analytical chemistry Sep, 2021 | Pubmed ID: 34541844
Adenovirus prevents dsRNA formation by promoting efficient splicing of viral RNA.
Nucleic acids research Feb, 2022 | Pubmed ID: 34671803
Subcellular Detection of SARS-CoV-2 RNA in Human Tissue Reveals Distinct Localization in Alveolar Type 2 Pneumocytes and Alveolar Macrophages.
mBio Feb, 2021 | Pubmed ID: 35130722
Detection and Interspecies Comparison of SARS-CoV-2 Delta Variant (AY.3) in Feces from a Domestic Cat and Human Samples.
bioRxiv : the preprint server for biology Feb, 2022 | Pubmed ID: 35132417
SARS-CoV-2 Delta Variant (AY.3) in the Feces of a Domestic Cat.
Viruses Feb, 2022 | Pubmed ID: 35216014
MERS-CoV endoribonuclease and accessory proteins jointly evade host innate immunity during infection of lung and nasal epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America May, 2022 | Pubmed ID: 35594398
SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1α/XBP1 ER stress pathway in human lung-derived cells.
bioRxiv : the preprint server for biology Jun, 2022 | Pubmed ID: 35821981
Targeted Mutations in the Fusion Peptide Region of La Crosse Virus Attenuate Neuroinvasion and Confer Protection against Encephalitis.
Viruses Jul, 2022 | Pubmed ID: 35891445
SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry.
Nature Oct, 2022 | Pubmed ID: 36198800
Infection of primary nasal epithelial cells differentiates among lethal and seasonal human coronaviruses.
bioRxiv : the preprint server for biology Oct, 2022 | Pubmed ID: 36299422
Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children.
Science (New York, N.Y.) Feb, 2023 | Pubmed ID: 36538032
Publisher Correction: SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry.
Nature Jan, 2023 | Pubmed ID: 36624294
Author Correction: SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry.
Nature Feb, 2023 | Pubmed ID: 36747034
Infection of primary nasal epithelial cells differentiates among lethal and seasonal human coronaviruses.
Proceedings of the National Academy of Sciences of the United States of America Apr, 2023 | Pubmed ID: 37023127
Detection of blood-brain barrier disruption in brains of patients with COVID-19, but no evidence of brain penetration by SARS-CoV-2.
Acta neuropathologica Aug, 2023 | Pubmed ID: 37624381
Comparison of SARS-CoV-2 variants in primary human nasal cultures indicates Delta as most cytopathic and Omicron as fastest replicating.
bioRxiv : the preprint server for biology Aug, 2023 | Pubmed ID: 37662273
1Department of Microbiology, University of Pennsylvania,
2Penn Center for Research on Coronaviruses and Other Emerging Pathogens, Perelman School of Medicine, University of Pennsylvania,
3Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania,
4, Corporal Michael J. Crescenz VA Medical Center