Noam A. Cohen

Revision endoscopic sinus surgery.

Long-term follow-up of a multiloculated arachnoid cyst of the middle cranial fossa.

Laser-assisted cerebrospinal fluid leak repair: an animal model to test feasibility.

Laser-welded endoscopic endoluminal repair of iatrogenic esophageal perforation: an animal model.

In vivo laser tissue welding in the rabbit maxillary sinus.

Chitosan glycerophosphate-based semirigid dexamethasone eluting biodegradable stent.

Antibiotic eluting chitosan glycerophosphate implant in the setting of acute bacterial sinusitis: a rabbit model.

Endonasal laser tissue welding: first human experience.

Prevention and management of lacrimal duct injury.

T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection.

Vasoactive intestinal peptide regulates sinonasal mucociliary clearance and synergizes with histamine in stimulating sinonasal fluid secretion.

Mouse nasal epithelial innate immune responses to Pseudomonas aeruginosa quorum-sensing molecules require taste signaling components.

Synchronous verrucous carcinoma and inverted papilloma of the lacrimal sac: case report and clinical update.

The bitter taste receptor T2R38 is an independent risk factor for chronic rhinosinusitis requiring sinus surgery.

Role of the bitter taste receptor T2R38 in upper respiratory infection and chronic rhinosinusitis.

A role for airway taste receptor modulation in the treatment of upper respiratory infections.

Correlation of T2R38 taste phenotype and in vitro biofilm formation from nonpolypoid chronic rhinosinusitis patients.

The genetics of the bitter taste receptor T2R38 in upper airway innate immunity and implications for chronic rhinosinusitis.

Taste Receptors Mediate Sinonasal Immunity and Respiratory Disease.

Bitter and sweet taste tests are reflective of disease status in chronic rhinosinusitis.

Solitary chemosensory cells are a primary epithelial source of IL-25 in patients with chronic rhinosinusitis with nasal polyps.

Dysregulation of hypoxia inducible factor-1alpha in head and neck squamous cell carcinoma cell lines correlates with invasive potential.

Endoscopic sinus surgery: where we are-and where we're going.

Surgical decisions in the management of frontal sinus osteomas.

Endoscopic resection of a venous hemangioma of the optic nerve sheath.

Quantification of ciliary beat frequency in sinonasal epithelial cells using differential interference contrast microscopy and high-speed digital video imaging.

Familial aggregation of sinonasal polyps correlates with severity of disease.

Regional analysis of sinonasal ciliary beat frequency.

Altered sinonasal ciliary dynamics in chronic rhinosinusitis.

Sinonasal mucociliary clearance in health and disease.

Mucociliary clearance--a critical upper airway host defense mechanism and methods of assessment.

An animal model for the study of topical medications in sinusitis.

Evaluation of the in vivo efficacy of topical tobramycin against Pseudomonas sinonasal biofilms.

Surfactant protein B detection and gene expression in chronic rhinosinusitis.

Reversal of chronic rhinosinusitis-associated sinonasal ciliary dysfunction.

Murine nasal septa for respiratory epithelial air-liquid interface cultures.

Dose-dependent effects of topical tobramycin in an animal model of Pseudomonas sinusitis.

Activated Vav2 modulates cellular invasion through Rac1 and Cdc42 in oral squamous cell carcinoma.

Murine tracheal and nasal septal epithelium for air-liquid interface cultures: a comparative study.

Clinical outcomes of endoscopic and endoscopic-assisted resection of inverted papillomas: a 15-year experience.

Transient receptor potential vanilloid type 4 channel expression in chronic rhinosinusitis.

Baby shampoo nasal irrigations for the symptomatic post-functional endoscopic sinus surgery patient.

Intraoperative IGS/CT updates for complex endoscopic frontal sinus surgery.

Spontaneous CSF leaks: a paradigm for definitive repair and management of intracranial hypertension.

An in vitro model of Pseudomonas aeruginosa biofilms on viable airway epithelial cell monolayers.

Prevalence of biofilm-forming bacteria in chronic rhinosinusitis.

Effects of an LL-37-derived antimicrobial peptide in an animal model of biofilm Pseudomonas sinusitis.

Cigarette smoke condensate inhibits transepithelial chloride transport and ciliary beat frequency.

Biofilms in chronic rhinosinusitis: a review.

Biofilms correlate with TH1 inflammation in the sinonasal tissue of patients with chronic rhinosinusitis.

Epithelium, cilia, and mucus: their importance in chronic rhinosinusitis.

Biofilms in chronic rhinosinusitis.

Secondhand smoke inhibits both Cl- and K+ conductances in normal human bronchial epithelial cells.

In vivo effects of citric acid/zwitterionic surfactant cleansing solution on rabbit sinus mucosa.

Cilia dysfunction.

Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase.

Pharmacologic activation of the innate immune system to prevent respiratory viral infections.

Tobacco smoke mediated induction of sinonasal microbial biofilms.

Clinical factors associated with bacterial biofilm formation in chronic rhinosinusitis.

Murine ciliotoxicity and rabbit sinus mucosal healing by polyhydrated ionogen.

Cellular adaptive inflammation mediates airway granulation in a murine model of subglottic stenosis.

A role for two-pore K⁺ channels in modulating Na⁺ absorption and Cl⁻ secretion in normal human bronchial epithelial cells.

Regulation of virulence gene expression resulting from Streptococcus pneumoniae and nontypeable Haemophilus influenzae interactions in chronic disease.

One-way valve bottle contamination rates in the immediate post-functional endoscopic sinus surgery period.

Regulation of murine sinonasal cilia function by microbial secreted factors.

Polyhydrated ionogen enhances postoperative sinonasal ciliated remucosalization.

Safety evaluation of sinus surfactant solution on respiratory cilia function.

Keratinocyte chemoattractant (interleukin-8) regulation of sinonasal cilia function in a murine model.

Acquired cilia dysfunction in chronic rhinosinusitis.

Molecular modulation of airway epithelial ciliary response to sneezing.

Molecular basis of tobacco-induced bacterial biofilms: an in vitro study.

GABA and glutamate are not colocalized in mossy fiber terminals of developing rodent hippocampus.

Nasal tip angiolipoma: the "Pinocchio" nasal deformity.

Pulse steroid therapy inhibits murine subglottic granulation.

The novel dry extract BNO 1011 stimulates chloride transport and ciliary beat frequency in human respiratory epithelial cultures.

Genetics of the taste receptor T2R38 correlates with chronic rhinosinusitis necessitating surgical intervention.

Surfactants in the management of rhinopathologies.

The emerging role of the bitter taste receptor T2R38 in upper respiratory infection and chronic rhinosinusitis.

Polyhydrated ionogen with MgBr2 accelerates in vitro respiratory epithelial healing.

The effect of diabetes mellitus on chronic rhinosinusitis and sinus surgery outcome.

Culture-inappropriate antibiotic therapy decreases quality of life improvement after sinus surgery.

Bitter and sweet taste receptors regulate human upper respiratory innate immunity.

Inflammatory protein expression in human subglottic stenosis tissue mirrors that in a murine model.

Traumatic brain injury-induced ependymal ciliary loss decreases cerebral spinal fluid flow.

In vitro studies of a distillate of rectified essential oils on sinonasal components of mucociliary clearance.

IL-17A induces Pendrin expression and chloride-bicarbonate exchange in human bronchial epithelial cells.

Sinonasal solitary chemosensory cells "taste" the upper respiratory environment to regulate innate immunity.

Quality of life improvement from sinus surgery in chronic rhinosinusitis patients with asthma and nasal polyps.

Taste receptors in innate immunity.

Coagulase-negative Staphylococcus culture in chronic rhinosinusitis.

Bitter and sweet taste receptors in the respiratory epithelium in health and disease.

Non-specific immunostaining by a rabbit antibody against gustducin α subunit in mouse brain.

The effect of drugs and other compounds on the ciliary beat frequency of human respiratory epithelium.

Phenylthiocarbamide taste sensitivity is associated with sinonasal symptoms in healthy adults.

Biofilm-forming bacteria and quality of life improvement after sinus surgery.

Corticosteroid use does not alter nasal mucus glucose in chronic rhinosinusitis.

Different clinical factors associated with Staphylococcus aureus and Pseudomonas aeruginosa in chronic rhinosinusitis.

Staphylococcus aureus triggers nitric oxide production in human upper airway epithelium.

Sinus irrigations before and after surgery-Visualization through computational fluid dynamics simulations.

The Role of Bitter and Sweet Taste Receptors in Upper Airway Immunity.

Optimized Protocol of Methanol Treatment for Immunofluorescent Staining in Fixed Brain Slices.

TAS2R38 genotype predicts surgical outcome in nonpolypoid chronic rhinosinusitis.

Chronic rhinosinusitis pathogenesis.

T2R38 genotype is correlated with sinonasal quality of life in homozygous ΔF508 cystic fibrosis patients.

Medical management of chronic rhinosinusitis - an update.

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis.

Human upper airway epithelium produces nitric oxide in response to Staphylococcus epidermidis.

Fungal Aflatoxins Reduce Respiratory Mucosal Ciliary Function.

Expression of dermcidin in human sinonasal secretions.

New insights into upper airway innate immunity.

Interleukin-17A (IL-17A) and IL-17F Are Critical for Antimicrobial Peptide Production and Clearance of Staphylococcus aureus Nasal Colonization.

Taste Receptors: Regulators of Sinonasal Innate Immunity.

Myrtol standardized affects mucociliary clearance.

TNF Affects Ciliary Beat Response to Increased Viscosity in Human Pediatric Airway Epithelium.

Nitric oxide production is stimulated by bitter taste receptors ubiquitously expressed in the sinonasal cavity.

Denatonium-induced sinonasal bacterial killing may play a role in chronic rhinosinusitis outcomes.

Relative susceptibility of airway organisms to antimicrobial effects of nitric oxide.

Effects of ophthalmologic solutions on sinonasal ciliated epithelium.

Sinonasal T2R-mediated nitric oxide production in response to .

CALHM1-Mediated ATP Release and Ciliary Beat Frequency Modulation in Nasal Epithelial Cells.

Medical management of chronic rhinosinusitis - a review of traditional and novel medical therapies.

Bacterial d-amino acids suppress sinonasal innate immunity through sweet taste receptors in solitary chemosensory cells.

Trefoil Factor 2 Promotes Type 2 Immunity and Lung Repair through Intrinsic Roles in Hematopoietic and Nonhematopoietic Cells.

Preoperative Lund-Mackay computed tomography score is associated with preoperative symptom severity and predicts quality-of-life outcome trajectories after sinus surgery.

Taste Receptor Polymorphisms and Immune Response: A Review of Receptor Genotypic-Phenotypic Variations and Their Relevance to Chronic Rhinosinusitis.

The Role of Quinine-Responsive Taste Receptor Family 2 in Airway Immune Defense and Chronic Rhinosinusitis.

Solitary chemosensory cells producing interleukin-25 and group-2 innate lymphoid cells are enriched in chronic rhinosinusitis with nasal polyps.

Sentinels at the wall: epithelial-derived cytokines serve as triggers of upper airway type 2 inflammation.

Macrophages promote epithelial proliferation following infectious and non-infectious lung injury through a Trefoil factor 2-dependent mechanism.

Biomarkers in Chronic Rhinosinusitis with Nasal Polyps.

Tissue-Dependent Expression of Bitter Receptor TAS2R38 mRNA.

Species-level bacterial community profiling of the healthy sinonasal microbiome using Pacific Biosciences sequencing of full-length 16S rRNA genes.

Role of Taste Receptors as Sentinels of Innate Immunity in the Upper Airway.

The human olfactory cleft mucus proteome and its age-related changes.

The role of bitter and sweet taste receptors in upper airway innate immunity: Recent advances and future directions.

Broncho-Vaxom® (OM-85 BV) soluble components stimulate sinonasal innate immunity.

Understanding the Role of Biofilms and Superantigens in Chronic Rhinosinusitis.

Fungal extracts stimulate solitary chemosensory cell expansion in noninvasive fungal rhinosinusitis.

Development of solitary chemosensory cells in the distal lung after severe influenza injury.

Inverted papilloma with multifocal attachment is associated with increased recurrence.

Characterization of Injury Induced by Routine Surgical Manipulations of Nasal Septal Cartilage.

Impact of age on outcomes following endoscopic sinus surgery for chronic rhinosinusitis.

Clinical Implications of Carcinoma In Situ in Sinonasal Inverted Papilloma.

Chronic rhinosinusitis precipitated by tumor necrosis factor alpha inhibitors is the phenotype of chronic rhinosinusitis without nasal polyps.

Inverted papilloma is associated with greater radiographic inflammatory disease than other sinonasal malignancy.

In vitro safety of ketotifen as a topical nasal rinse.

Aerosol or droplet: critical definitions in the COVID-19 era.

Divergent bitter and sweet taste perception intensity in chronic rhinosinusitis patients.

Denatonium benzoate bitter taste perception in chronic rhinosinusitis subgroups.

Solitary chemosensory cells are innervated by trigeminal nerve endings and autoregulated by cholinergic receptors.

Tuft cells in the pathogenesis of chronic rhinosinusitis with nasal polyps and asthma.

Cellular context of IL-33 expression dictates impact on anti-helminth immunity.

International Consensus Statement on Rhinology and Allergy: Rhinosinusitis.

Bitter Taste Receptors and Chronic Otitis Media.

Bitter taste receptor agonists regulate epithelial two-pore potassium channels via cAMP signaling.

Multidisciplinary single-center outcomes compared to two-center outcomes for the treatment of aspirin exacerbated respiratory disease.

Objective screening for olfactory and gustatory dysfunction during the COVID-19 pandemic: a prospective study in healthcare workers using self-administered testing.

Dynamic Changes in the Nasal Microbiome Associated With Disease Activity in Patients With Granulomatosis With Polyangiitis.

SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes.

LINGO3 regulates mucosal tissue regeneration and promotes TFF2 dependent recovery from colitis.

The GSDMB rs7216389 SNP is associated with chronic rhinosinusitis in a multi-institutional cohort.

Blocking Cross-Species Secondary Binding When Performing Double Immunostaining With Mouse and Rat Primary Antibodies.

Epithelial dysregulation in chronic rhinosinusitis with nasal polyposis (CRSwNP) and aspirin-exacerbated respiratory disease (AERD).

Targeted gene expression profiling of inverted papilloma and squamous cell carcinoma.

Trefoil Factor Family: A Troika for Lung Repair and Regeneration.

Persistent Inflammation and Nitric Oxide Dysregulation Are Transcriptomic Blueprints of Subglottic Stenosis.

Association between the HLA-DQA1 rs1391371 risk allele and chronic rhinosinusitis.

Steroid affected cytokines in aspirin-exacerbated respiratory disease.

Evaluating enrollment and outcome criteria in trials of biologics for chronic rhinosinusitis with nasal polyps.

Nicotinic acetylcholine receptor stimulation: A new approach for stimulating tear secretion in dry eye disease.

MERS-CoV endoribonuclease and accessory proteins jointly evade host innate immunity during infection of lung and nasal epithelial cells.

Impact of dupilumab on SNOT-22 sleep and function scores in CRSwNP.

Impact of sweet, umami, and bitter taste receptor (TAS1R and TAS2R) genomic and expression alterations in solid tumors on survival.

Improvement in Health-Related Quality of Life with Dupilumab in Patients with Moderate-to-Severe Asthma with Comorbid Chronic Rhinosinusitis with/without Nasal Polyps: An Analysis of the QUEST Study.

Genetics of denatonium-responsive bitter receptors in aspirin-exacerbated respiratory disease.

Injury-induced pulmonary tuft cells are heterogenous, arise independent of key Type 2 cytokines, and are dispensable for dysplastic repair.

Infection of primary nasal epithelial cells differentiates among lethal and seasonal human coronaviruses.

Microbial metabolite succinate activates solitary chemosensory cells in the human sinonasal epithelium.

Infection of primary nasal epithelial cells differentiates among lethal and seasonal human coronaviruses.

Detection and verification of neurodegeneration after traumatic brain injury in the mouse: Immunohistochemical staining for amyloid precursor protein.

A metagenomic analysis of the virome of inverted papilloma and squamous cell carcinoma.

Comparison of SARS-CoV-2 variants in primary human nasal cultures indicates Delta as most cytopathic and Omicron as fastest replicating.

Long-term aspirin desensitization has mucosal cytokine features of immune tolerance.