Centre for Medicines Discovery,
Nuffield Department of Medicine,
Centre for Medicines Discovery, Nuffield Department of Medicine
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Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study.
Protein expression and purification May, 2008 | Pubmed ID: 18289875
High throughput production of recombinant human proteins for crystallography.
Methods in molecular biology (Clifton, N.J.) , 2008 | Pubmed ID: 18542867
Large-scale structural analysis of the classical human protein tyrosine phosphatome.
Cell Jan, 2009 | Pubmed ID: 19167335
High-throughput production of human proteins for crystallization: the SGC experience.
Journal of structural biology Oct, 2010 | Pubmed ID: 20541610
A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation.
Nucleic acids research Mar, 2011 | Pubmed ID: 21059676
Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair.
Genes & development Sep, 2011 | Pubmed ID: 21896658
Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation.
New biotechnology Jun, 2012 | Pubmed ID: 22027370
The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4.
Journal of molecular biology Sep, 2012 | Pubmed ID: 22575888
The structural basis of ZMPSTE24-dependent laminopathies.
Science (New York, N.Y.) Mar, 2013 | Pubmed ID: 23539603
Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2013 | Pubmed ID: 23716676
Structural insights into functional overlapping and differentiation among myosin V motors.
The Journal of biological chemistry Nov, 2013 | Pubmed ID: 24097982
Medium-throughput production of recombinant human proteins: ligation-independent cloning.
Methods in molecular biology (Clifton, N.J.) , 2014 | Pubmed ID: 24203324
Medium-throughput production of recombinant human proteins: protein production in E. coli.
Methods in molecular biology (Clifton, N.J.) , 2014 | Pubmed ID: 24203325
Medium-throughput production of recombinant human proteins: protein production in insect cells.
Methods in molecular biology (Clifton, N.J.) , 2014 | Pubmed ID: 24203326
Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching.
Epigenetics & chromatin , 2014 | Pubmed ID: 25097667
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.
Science (New York, N.Y.) Mar, 2015 | Pubmed ID: 25766236
Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis.
Annals of the rheumatic diseases Jun, 2016 | Pubmed ID: 26209657
Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.
MedChemComm Dec, 2014 | Pubmed ID: 26682034
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.
Journal of medicinal chemistry Feb, 2016 | Pubmed ID: 26741168
Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).
Nature structural & molecular biology Feb, 2017 | Pubmed ID: 27991905
Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.
Cell chemical biology Mar, 2017 | Pubmed ID: 28262558
The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery.
Essays in biochemistry Nov, 2017 | Pubmed ID: 29118096
Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.
Cell Nov, 2018 | Pubmed ID: 30388443
High-Throughput Site-Directed Mutagenesis.
Methods in molecular biology (Clifton, N.J.) , 2019 | Pubmed ID: 31267458
The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
Nature communications Sep, 2019 | Pubmed ID: 31477691
A lower X-gate in TASK channels traps inhibitors within the vestibule.
Nature Jun, 2020 | Pubmed ID: 32499642
Screening and Production of Recombinant Human Proteins: Ligation-Independent Cloning.
Methods in molecular biology (Clifton, N.J.) , 2021 | Pubmed ID: 33125643
Screening and Production of Recombinant Human Proteins: Protein Production in E. coli.
Methods in molecular biology (Clifton, N.J.) , 2021 | Pubmed ID: 33125644
Screening and Production of Recombinant Human Proteins: Protein Production in Insect Cells.
Methods in molecular biology (Clifton, N.J.) , 2021 | Pubmed ID: 33125645
Expression Screening of Human Integral Membrane Proteins Using BacMam.
Methods in molecular biology (Clifton, N.J.) , 2021 | Pubmed ID: 33125646
Structure and activation mechanism of the human liver-type glutaminase GLS2.
Biochimie Jun, 2021 | Pubmed ID: 33746066
Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.
The EMBO journal Jul, 2021 | Pubmed ID: 34031912
The structural basis of fatty acid elongation by the ELOVL elongases.
Nature structural & molecular biology Jun, 2021 | Pubmed ID: 34117479
Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain.
Structure (London, England : 1993) Nov, 2021 | Pubmed ID: 34233201
Beyond Just Peptide Antigens: The Complex World of Peptide-Based Cancer Vaccines.
Frontiers in immunology , 2021 | Pubmed ID: 34276688
Identification, mapping and relative quantitation of SARS-CoV-2 Spike glycopeptides by Mass-Retention Time Fingerprinting.
Communications biology Aug, 2021 | Pubmed ID: 34345007
FAS2FURIOUS: Moderate-Throughput Secreted Expression of Difficult Recombinant Proteins in S2 Cells.
Frontiers in bioengineering and biotechnology , 2022 | Pubmed ID: 35600892
Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain.
Nature communications Jul, 2022 | Pubmed ID: 35840580
Sagar Raturi1,
Huanyu Li1,
Yung-Ning Chang2,
Andreea Scacioc1,
Tina Bohstedt1,
Alejandra Fernandez-Cid1,
Adam Evans1,
Patrizia Abrusci1,
Abilasha Balakrishnan1,
Tomas C. Pascoa1,
Didi He1,
Gamma Chi1,
Nanki Kaur Singh1,
Mingda Ye1,
Anna Li1,
Leela Shrestha1,
Dong Wang1,
Eleanor P. Williams1,
Nicola A. Burgess-Brown1,
Katharina L. Dürr1,
Vera Puetter2,
Alvaro Ingles-Prieto3,
David B. Sauer1