Nicola A. Burgess-Brown

Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study.

High throughput production of recombinant human proteins for crystallography.

Large-scale structural analysis of the classical human protein tyrosine phosphatome.

High-throughput production of human proteins for crystallization: the SGC experience.

A prominent β-hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation.

Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair.

Expressing the human proteome for affinity proteomics: optimising expression of soluble protein domains and in vivo biotinylation.

The PHD and chromo domains regulate the ATPase activity of the human chromatin remodeler CHD4.

The structural basis of ZMPSTE24-dependent laminopathies.

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.

Structural insights into functional overlapping and differentiation among myosin V motors.

Medium-throughput production of recombinant human proteins: ligation-independent cloning.

Medium-throughput production of recombinant human proteins: protein production in E. coli.

Medium-throughput production of recombinant human proteins: protein production in insect cells.

Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching.

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac.

Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis.

Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.

8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).

Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells.

The SGC beyond structural genomics: redefining the role of 3D structures by coupling genomic stratification with fragment-based discovery.

Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.

High-Throughput Site-Directed Mutagenesis.

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.

A lower X-gate in TASK channels traps inhibitors within the vestibule.

Screening and Production of Recombinant Human Proteins: Ligation-Independent Cloning.

Screening and Production of Recombinant Human Proteins: Protein Production in E. coli.

Screening and Production of Recombinant Human Proteins: Protein Production in Insect Cells.

Expression Screening of Human Integral Membrane Proteins Using BacMam.

Structure and activation mechanism of the human liver-type glutaminase GLS2.

Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.

The structural basis of fatty acid elongation by the ELOVL elongases.

Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain.

Beyond Just Peptide Antigens: The Complex World of Peptide-Based Cancer Vaccines.

Identification, mapping and relative quantitation of SARS-CoV-2 Spike glycopeptides by Mass-Retention Time Fingerprinting.

FAS2FURIOUS: Moderate-Throughput Secreted Expression of Difficult Recombinant Proteins in S2 Cells.

Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain.