Eric Bindels

Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes.

Gli1 Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.

Increased CXCL4 expression in hematopoietic cells links inflammation and progression of bone marrow fibrosis in MPN.

Only Hyperuricemia with Crystalluria, but not Asymptomatic Hyperuricemia, Drives Progression of Chronic Kidney Disease.

Decoding myofibroblast origins in human kidney fibrosis.

Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis.

Causal integration of multi-omics data with prior knowledge to generate mechanistic hypotheses.

Allele-specific expression of GATA2 due to epigenetic dysregulation in CEBPA double-mutant AML.

Genetic barcoding systematically compares genes in del(5q) MDS and reveals a central role for CSNK1A1 in clonal expansion.

Single-cell analysis of cultured bone marrow stromal cells reveals high similarity to fibroblasts in situ.

Mapping the cardiac vascular niche in heart failure.

Spatial multi-omic map of human myocardial infarction.

Adult human kidney organoids originate from CD24 cells and represent an advanced model for adult polycystic kidney disease.

Gata2-regulated Gfi1b expression controls endothelial programming during endothelial-to-hematopoietic transition.

A combinatorial panel for flow cytometry-based isolation of enteric nervous system cells from human intestine.