Frederick F. Lang

Department of Neurosurgery, The University of Texas MD Anderson Cancer Center

Affiliated withThe University of Texas MD Anderson Cancer Center

Research Area

Cancer Research

Biography

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JoVE Journal Publications

ArticleTotal : 1	Year
Publication title	2024

Other Publications

Article	Year
Surgical resection of intrinsic insular tumors: complication avoidance. Journal of neurosurgery\| PubMed ID: 11596959	2001
Toward better early-phase brain tumor clinical trials: a reappraisal of current methods and proposals for future strategies. Neuro-oncology\| PubMed ID: 12356357	2002
Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: biological and clinical results. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 12839017	2003
A novel E1A-E1B mutant adenovirus induces glioma regression in vivo. Oncogene\| PubMed ID: 15014451	2004
Prospective clinical trials of brain tumor therapy: the critical role of neurosurgeons. Journal of neuro-oncology\| PubMed ID: 15527087	2004
Delta24-hyCD adenovirus suppresses glioma growth in vivo by combining oncolysis and chemosensitization. Cancer gene therapy\| PubMed ID: 15650766	2005
Diffusely infiltrative low-grade gliomas in adults. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 16525178	2006
Delta-24-RGD in combination with RAD001 induces enhanced anti-glioma effect via autophagic cell death. Molecular therapy : the journal of the American Society of Gene Therapy\| PubMed ID: 18253154	2008
Targeting gelatinases with a near-infrared fluorescent cyclic His-Try-Gly-Phe peptide. Molecular imaging and biology\| PubMed ID: 19424760	2009
High rate of deletion of chromosomes 1p and 19q in insular oligodendroglial tumors. Journal of neuro-oncology\| PubMed ID: 20035368	2010
Genetic and epigenetic modifications of Sox2 contribute to the invasive phenotype of malignant gliomas. PloS one\| PubMed ID: 22069467	2011
REST regulates oncogenic properties of glioblastoma stem cells. Stem cells (Dayton, Ohio)\| PubMed ID: 22228704	2012
TGF-Î² mediates homing of bone marrow-derived human mesenchymal stem cells to glioma stem cells. Cancer research\| PubMed ID: 23365134	2013
A prospective randomized trial of perioperative seizure prophylaxis in patients with intraparenchymal brain tumors. Journal of neurosurgery\| PubMed ID: 23394340	2013
miR-124 inhibits STAT3 signaling to enhance T cell-mediated immune clearance of glioma. Cancer research\| PubMed ID: 23636127	2013
A high Notch pathway activation predicts response to γ secretase inhibitors in proneural subtype of glioma tumor-initiating cells. Stem cells (Dayton, Ohio)\| PubMed ID: 24038660	2014
Extent of resection of glioblastoma revisited: personalized survival modeling facilitates more accurate survival prediction and supports a maximum-safe-resection approach to surgery. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 24516010	2014
Two mature products of MIR-491 coordinate to suppress key cancer hallmarks in glioblastoma. Oncogene\| PubMed ID: 24747968	2015
Delta-24-RGD oncolytic adenovirus elicits anti-glioma immunity in an immunocompetent mouse model. PloS one\| PubMed ID: 24827739	2014
A history of the AANS/CNS Section on Tumors Biennial Satellite Symposium. Journal of neuro-oncology\| PubMed ID: 25081975	2014
FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells. Cancer research\| PubMed ID: 25832656	2015
Oncolytic adenovirus research evolution: from cell-cycle checkpoints to immune checkpoints. Current opinion in virology\| PubMed ID: 25863716	2015
ESI-MS/MS and MALDI-IMS Localization Reveal Alterations in Phosphatidic Acid, Diacylglycerol, and DHA in Glioma Stem Cell Xenografts. Journal of proteome research\| PubMed ID: 25880480	2015
Mesenchymal Stem Cells Isolated From Human Gliomas Increase Proliferation and Maintain Stemness of Glioma Stem Cells Through the IL-6/gp130/STAT3 Pathway. Stem cells (Dayton, Ohio)\| PubMed ID: 25966666	2015
Integrated Transcriptomic and Glycomic Profiling of Glioma Stem Cell Xenografts. Journal of proteome research\| PubMed ID: 26185906	2015
Genetic, epigenetic, and molecular landscapes of multifocal and multicentric glioblastoma. Acta neuropathologica\| PubMed ID: 26323991	2015
Suppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells. Journal of translational medicine\| PubMed ID: 26861698	2016
Endoplasmic reticulum stress-inducing drugs sensitize glioma cells to temozolomide through downregulation of MGMT, MPG, and Rad51. Neuro-oncology\| PubMed ID: 26951384	2016
A Dexamethasone-regulated Gene Signature Is Prognostic for Poor Survival in Glioblastoma Patients. Journal of neurosurgical anesthesiology\| PubMed ID: 27653222	2017
TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1. Science advances\| PubMed ID: 27757426	2016
Preclinical Evaluation of Sequential Combination of Oncolytic Adenovirus Delta-24-RGD and Phosphatidylserine-Targeting Antibody in Pancreatic Ductal Adenocarcinoma. Molecular cancer therapeutics\| PubMed ID: 28138026	2017
Mesenchymal stromal cells for the delivery of oncolytic viruses in gliomas. Cytotherapy\| PubMed ID: 28233640	2017
Ionizing radiation augments glioma tropism of mesenchymal stem cells. Journal of neurosurgery\| PubMed ID: 28362237	2018
Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination. Cancer research\| PubMed ID: 28566332	2017
Efficacy of Onalespib, a Long-Acting Second-Generation HSP90 Inhibitor, as a Single Agent and in Combination with Temozolomide against Malignant Gliomas. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 28679777	2017
Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial. The Lancet. Oncology\| PubMed ID: 28687375	2017
TIE2 Associates with Caveolae and Regulates Caveolin-1 To Promote Their Nuclear Translocation. Molecular and cellular biology\| PubMed ID: 28760776	2017
Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells via Transfer of miR-1587. Cancer research\| PubMed ID: 28855213	2017
Mesenchymal stem cells as natural biofactories for exosomes carrying miR-124a in the treatment of gliomas. Neuro-oncology\| PubMed ID: 29016843	2018
Dexamethasone-mediated oncogenicity in vitro and in an animal model of glioblastoma. Journal of neurosurgery\| PubMed ID: 29328002	2018
Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology\| PubMed ID: 29432077	2018
Magnetic resonance and photoacoustic imaging of brain tumor mediated by mesenchymal stem cell labeled with multifunctional nanoparticle introduced via carotid artery injection. Nanotechnology\| PubMed ID: 29438105	2018
A gene expression signature predicts recurrence-free survival in meningioma. Oncotarget\| PubMed ID: 29662628	2018
MRI venous architecture of insula. Journal of the neurological sciences\| PubMed ID: 29801878	2018
A Coclinical Radiogenomic Validation Study: Conserved Magnetic Resonance Radiomic Appearance of Periostin-Expressing Glioblastoma in Patients and Xenograft Models. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 30054278	2018
Distinct mechanisms enable inward or outward budding from late endosomes/multivesicular bodies. Experimental cell research\| PubMed ID: 30144444	2018
Perilesional Resection of Glioblastoma Is Independently Associated With Improved Outcomes. Neurosurgery\| PubMed ID: 30799490	2020
REST-DRD2 mechanism impacts glioblastoma stem cell-mediated tumorigenesis. Neuro-oncology\| PubMed ID: 30953587	2019
Biological subtypes and survival outcomes in breast cancer patients with brain metastases in the targeted therapy era. Neuro-oncology practice\| PubMed ID: 31386016	2018
Localized Treatment with Oncolytic Adenovirus Delta-24-RGDOX Induces Systemic Immunity against Disseminated Subcutaneous and Intracranial Melanomas. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 31455679	2019
Microcatheter delivery of neurotherapeutics: compatibility with mesenchymal stem cells. Journal of neurosurgery\| PubMed ID: 31491769	2019
GITRL-armed Delta-24-RGD oncolytic adenovirus prolongs survival and induces anti-glioma immune memory. Neuro-oncology advances\| PubMed ID: 31608328	2019
Advances in endovascular neuro-oncology: endovascular selective intra-arterial (ESIA) infusion of targeted biologic therapy for brain tumors. Journal of neurointerventional surgery\| PubMed ID: 31676690	2020
Window-of-opportunity clinical trial of pembrolizumab in patients with recurrent glioblastoma reveals predominance of immune-suppressive macrophages. Neuro-oncology\| PubMed ID: 31755915	2020
Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment. Cancer discovery\| PubMed ID: 31919052	2020
Glioblastoma-mediated Immune Dysfunction Limits CMV-specific T Cells and Therapeutic Responses: Results from a Phase I/II Trial. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 32299815	2020
A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities. Nature communications\| PubMed ID: 32523045	2020
The role of resting-state functional MRI for clinical preoperative language mapping. Cancer imaging : the official publication of the International Cancer Imaging Society\| PubMed ID: 32653026	2020
Profiling of patients with glioma reveals the dominant immunosuppressive axis is refractory to immune function restoration. JCI insight\| PubMed ID: 32721947	2020
Impact of anesthesia and analgesia techniques on glioblastoma progression. A narrative review. Neuro-oncology advances\| PubMed ID: 33205044	2020
Window of Opportunity Clinical Trials to Evaluate Novel Therapies for Brain Tumors. Neurosurgery clinics of North America\| PubMed ID: 33223031	2021
RNAi technology targeting the fusion breakpoint: an opportunity for precision medicine. Neuro-oncology advances\| PubMed ID: 33241214	2020
Considerations for designing preclinical cancer immune nanomedicine studies. Nature nanotechnology\| PubMed ID: 33349682	2021
Intraarterial delivery of virotherapy for glioblastoma. Neurosurgical focus\| PubMed ID: 33524944	2021
Delta-24 adenoviral therapy for glioblastoma: evolution from the bench to bedside and future considerations. Neurosurgical focus\| PubMed ID: 33524949	2021
The history of neurosurgery at Baylor College of Medicine. Journal of neurosurgery\| PubMed ID: 33607618	2021
Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma. Cancer discovery\| PubMed ID: 34039636	2021
An immune-competent, replication-permissive Syrian Hamster glioma model for evaluating Delta-24-RGD oncolytic adenovirus. Neuro-oncology\| PubMed ID: 34059921	2021
Targeting the αv integrin/TGF-β axis improves natural killer cell function against glioblastoma stem cells. The Journal of clinical investigation\| PubMed ID: 34138753	2021
Hitchhiking to brain tumours: stem cell delivery of oncolytic viruses. The Lancet. Oncology\| PubMed ID: 34214494	2021
Inhibition of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of the nicotinamide adenine dinucleotide (NAD) salvage pathway, to target glioma heterogeneity through ... Neuro-oncology\| PubMed ID: 34260721	2022
Characterization of patient-derived bone marrow human mesenchymal stem cells as oncolytic virus carriers for the treatment of glioblastoma. Journal of neurosurgery\| PubMed ID: 34450587	2022
Measuring the Metabolic Evolution of Glioblastoma throughout Tumor Development, Regression, and Recurrence with Hyperpolarized Magnetic Resonance. Cells\| PubMed ID: 34685601	2021
Intrinsic Interferon Signaling Regulates the Cell Death and Mesenchymal Phenotype of Glioblastoma Stem Cells. Cancers\| PubMed ID: 34771447	2021
Perfusion-guided endovascular super-selective intra-arterial infusion for treatment of malignant brain tumors. Journal of neurointerventional surgery\| PubMed ID: 34824133	2022
Circumferential sulcus-guided resection technique for improved outcomes of low-grade gliomas. Journal of neurosurgery\| PubMed ID: 34996044	2022
Long term outcomes following surgery for pineal region tumors. Journal of neuro-oncology\| PubMed ID: 35083579	2022
Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target. Nature communications\| PubMed ID: 35140215	2022
Convection Enhanced Delivery of the Oncolytic Adenovirus Delta24-RGD in Patients with Recurrent GBM: A Phase I Clinical Trial Including Correlative Studies. Clinical cancer research : an official journal of the American Association for Cancer Research\| PubMed ID: 35176144	2022
Preclinical animal brain tumor models for interventional neuro-oncology. Journal of neurointerventional surgery\| PubMed ID: 35414632	2022
A Window of Opportunity to Overcome Therapeutic Failure in Neuro-Oncology. American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting\| PubMed ID: 35580289	2022
An interdisciplinary consensus on the management of brain metastases in patients with renal cell carcinoma. CA: a cancer journal for clinicians\| PubMed ID: 35708940	2022
Reshaping the tumor microenvironment with oncolytic viruses, positive regulation of the immune synapse, and blockade of the immunosuppressive oncometabolic circuitry. Journal for immunotherapy of cancer\| PubMed ID: 35902132	2022
NMR Spectroscopy-Based Metabolomics of Platelets to Analyze Brain Tumors. Reports (MDPI)\| PubMed ID: 35937580	2021
Changes in outcomes and factors associated with survival in melanoma patients with brain metastases. Neuro-oncology\| PubMed ID: 36510640	2023
Comparison of pharmacological inhibitors of lysine-specific demethylase 1 in glioblastoma stem cells reveals inhibitor-specific efficacy profiles. Frontiers in neurology\| PubMed ID: 37082446	2023
Oncolytic DNX-2401 virotherapy plus pembrolizumab in recurrent glioblastoma: a phase 1/2 trial. Nature medicine\| PubMed ID: 37188783	2023
Adjuvant Therapy with Oncolytic Adenovirus Delta-24-RGDOX After Intratumoral Adoptive T-cell Therapy Promotes Antigen Spread to Sustain Systemic Antitumor Immunity. Cancer research communications\| PubMed ID: 37379361	2023
Multiomics analyses reveal /YBX1-controlled posttranscriptional circuits promoting glioblastoma tumorigenesis/radioresistance. Science advances\| PubMed ID: 37540752	2023
Myeloid-specific KDM6B inhibition sensitizes glioblastoma to PD1 blockade. Nature cancer\| PubMed ID: 37653141	2023
Tumor-specific polycistronic miRNA delivered by engineered exosomes for the treatment of glioblastoma. Neuro-oncology\| PubMed ID: 37847405	2024
Rapid detection of mutations in CSF-cfTNA with the Genexus Integrated Sequencer. Journal of neuro-oncology\| PubMed ID: 38160230	2024
MGMT function determines the differential response of ATR inhibitors with DNA-damaging agents in glioma stem cells for GBM therapy. Neuro-oncology advances\| PubMed ID: 38213834	2024
Triggering receptor expressed on myeloid cells 2 (TREM2) regulates phagocytosis in glioblastoma. Neuro-oncology\| PubMed ID: 38237157	2024
The genomic alterations in glioblastoma influence the levels of CSF metabolites. Acta neuropathologica communications\| PubMed ID: 38243318	2024
Collision tumor: Multinodular and vacuolating neuronal tumor with isocitrate dehydrogenase-mutant diffuse astrocytoma. Neuropathology : official journal of the Japanese Society of Neuropathology\| PubMed ID: 38414131	2024