Laura M. Sly

Salmonella enterica serovar Typhimurium periplasmic superoxide dismutases SodCI and SodCII are required for protection against the phagocyte oxidative burst.

Survival of Mycobacterium tuberculosis in host macrophages involves resistance to apoptosis dependent upon induction of antiapoptotic Bcl-2 family member Mcl-1.

The 19-kDa Mycobacterium tuberculosis protein induces macrophage apoptosis through Toll-like receptor-2.

Monocyte p110alpha phosphatidylinositol 3-kinase regulates phagocytosis, the phagocyte oxidase, and cytokine production.

The role of SHIP in macrophages.

The inositol phosphatase SHIP controls Salmonella enterica serovar Typhimurium infection in vivo.

SHIP prevents lipopolysaccharide from triggering an antiviral response in mice.

SHIP regulates the reciprocal development of T regulatory and Th17 cells.

SHIP represses the generation of IL-3-induced M2 macrophages by inhibiting IL-4 production from basophils.

The p110α and p110β isoforms of class I phosphatidylinositol 3-kinase are involved in toll-like receptor 5 signaling in epithelial cells.

SHIP represses Th2 skewing by inhibiting IL-4 production from basophils.

Alternative activation of macrophages by IL-4 requires SHIP degradation.

SHIP-deficient mice develop spontaneous intestinal inflammation and arginase-dependent fibrosis.

A low carbohydrate, high protein diet slows tumor growth and prevents cancer initiation.

SHIP-deficient, alternatively activated macrophages protect mice during DSS-induced colitis.

Generation and characterization of murine alternatively activated macrophages.

Combined immunodeficiency associated with homozygous MALT1 mutations.

Arginase activity in alternatively activated macrophages protects PI3Kp110δ deficient mice from dextran sodium sulfate induced intestinal inflammation.

Impaired NLRP3 inflammasome activity during fetal development regulates IL-1β production in human monocytes.

Phosphatase regulation of macrophage activation.

Intravenous immunoglobulin skews macrophages to an anti-inflammatory, IL-10-producing activation state.

Activity of SHIP, Which Prevents Expression of Interleukin 1β, Is Reduced in Patients With Crohn's Disease.

Endosomal pH modulation by peptide-gold nanoparticle hybrids enables potent anti-inflammatory activity in phagocytic immune cells.

IFN-γ directly inhibits murine B-cell precursor leukemia-initiating cell proliferation early in life.