David J. Marcinek

Basal glycogenolysis in mouse skeletal muscle: in vitro model predicts in vivo fluxes.

Oxygen regulation and limitation to cellular respiration in mouse skeletal muscle in vivo.

Mitochondrial coupling in vivo in mouse skeletal muscle.

Reduced mitochondrial coupling in vivo alters cellular energetics in aged mouse skeletal muscle.

Mitochondrial function, fibre types and ageing: new insights from human muscle in vivo.

Mild mitochondrial uncoupling impacts cellular aging in human muscles in vivo.

Mitochondrial dysfunction: impact on exercise performance and cellular aging.

Wavelength shift analysis: a simple method to determine the contribution of hemoglobin and myoglobin to in vivo optical spectra.

Mitochondrial dysfunction and age.

Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy.

Mitochondrial function in vivo: spectroscopy provides window on cellular energetics.

Lactic acidosis in vivo: testing the link between lactate generation and H+ accumulation in ischemic mouse muscle.

Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria.

Mitochondrial oxidative stress mediates angiotensin II-induced cardiac hypertrophy and Galphaq overexpression-induced heart failure.

Reduced coupling of oxidative phosphorylation in vivo precedes electron transport chain defects due to mild oxidative stress in mice.

A novel antibody-based biomarker for chronic algal toxin exposure and sub-acute neurotoxicity.

Impaired adaptability of in vivo mitochondrial energetics to acute oxidative insult in aged skeletal muscle.

Defects in mitochondrial localization and ATP synthesis in the mdx mouse model of Duchenne muscular dystrophy are not alleviated by PDE5 inhibition.

Higher mitochondrial respiration and uncoupling with reduced electron transport chain content in vivo in muscle of sedentary versus active subjects.

Mitochondrial-targeted peptide rapidly improves mitochondrial energetics and skeletal muscle performance in aged mice.

Targeting redox biology to reverse mitochondrial dysfunction.

Mitochondrial oxidative stress in aging and healthspan.

Chronic low-level domoic acid exposure alters gene transcription and impairs mitochondrial function in the CNS.

In vivo metabolic spectroscopy identifies deficits in mitochondrial quality and capacity in aging skeletal muscle.

Effect of omega-3 fatty acid oxidation products on the cellular and mitochondrial toxicity of BDE 47.

Olfactory Transcriptional Analysis of Salmon Exposed to Mixtures of Chlorpyrifos and Malathion Reveal Novel Molecular Pathways of Neurobehavioral Injury.

Age modifies respiratory complex I and protein homeostasis in a muscle type-specific manner.

The Measurement of Reversible Redox Dependent Post-translational Modifications and Their Regulation of Mitochondrial and Skeletal Muscle Function.

Evaluation of in vivo mitochondrial bioenergetics in skeletal muscle using NMR and optical methods.

Nitric Oxide Regulates Skeletal Muscle Fatigue, Fiber Type, Microtubule Organization, and Mitochondrial ATP Synthesis Efficiency Through cGMP-Dependent Mechanisms.

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation.

Skeletal muscle bioenergetics in aging and heart failure.

The mitochondrial-targeted peptide, SS-31, improves glomerular architecture in mice of advanced age.

Acute and chronic dietary exposure to domoic acid in recreational harvesters: A survey of shellfish consumption behavior.

Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry.

Chronic low-level exposure to the common seafood toxin domoic acid causes cognitive deficits in mice.

Effect of contaminants of emerging concern on liver mitochondrial function in Chinook salmon.

Cyclophosphamide leads to persistent deficits in physical performance and in vivo mitochondria function in a mouse model of chemotherapy late effects.

Fatiguing contractions increase protein S-glutathionylation occupancy in mouse skeletal muscle.

Building strength, endurance, and mobility using an astaxanthin formulation with functional training in elderly.

Domoic acid in California sea lion fetal fluids indicates continuous exposure to a neuroteratogen poses risks to mammals.

Repeated low level domoic acid exposure increases CA1 VGluT1 levels, but not bouton density, VGluT2 or VGAT levels in the hippocampus of adult mice.

Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice.

Discovery of a Potential Human Serum Biomarker for Chronic Seafood Toxin Exposure Using an SPR Biosensor.

Mitochondrial protein interaction landscape of SS-31.

SS-31 and NMN: Two paths to improve metabolism and function in aged hearts.

Increased tumour burden alters skeletal muscle properties in the KPC mouse model of pancreatic cancer.

Reduction of elevated proton leak rejuvenates mitochondria in the aged cardiomyocyte.

High intensity muscle stimulation activates a systemic Nrf2-mediated redox stress response.

Are fat and sugar just as detrimental in old age?

Astaxanthin supplementation enhances metabolic adaptation with aerobic training in the elderly.

In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial.

Elamipretide (SS-31) treatment attenuates age-associated post-translational modifications of heart proteins.

A replication-linked mutational gradient drives somatic mutation accumulation and influences germline polymorphisms and genome composition in mitochondrial DNA.

Ice seals as sentinels for algal toxin presence in the Pacific Arctic and subarctic marine ecosystems.

An Analysis of Metabolic Changes in the Retina and Retinal Pigment Epithelium of Aging Mice.

Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults: A Randomized Clinical Trial.

Long-term treatment with Elamipretide enhances healthy aging phenotypes in mice.

Elamipretide effects on the skeletal muscle phosphoproteome in aged female mice.

Aging Increases Susceptibility to Develop Cardiac Hypertrophy following High Sugar Consumption.

Mitochondrial Energetics in Skeletal Muscle Are Associated With Leg Power and Cardiorespiratory Fitness in the Study of Muscle, Mobility and Aging.

dATP elevation induces myocardial metabolic remodeling to support improved cardiac function.

The Study of Muscle, Mobility and Aging (SOMMA): A Unique Cohort Study About the Cellular Biology of Aging and Age-related Loss of Mobility.

Elamipretide Improves ADP Sensitivity in Aged Mitochondria by Increasing Uptake through the Adenine Nucleotide Translocator (ANT).

The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging.

From mitochondria to cells to humans: Targeting bioenergetics in aging and disease.

ATP and NAD Deficiency in Parkinson's Disease.

Intermittent treatment with elamipretide preserves exercise tolerance in aged female mice.

Age and Sex as Determinants of Acute Domoic Acid Toxicity in a Mouse Model.

Skeletal muscle mitochondrial interactome remodeling is linked to functional decline in aged female mice.

Randomized crossover clinical trial of coenzyme Q10 and nicotinamide riboside in chronic kidney disease.

A novel mitochondrial complex I ROS inhibitor partially improves muscle regeneration in adult but not old mice.

The mitochondrially targeted peptide elamipretide (SS-31) improves ADP sensitivity in aged mitochondria by increasing uptake through the adenine nucleotide translocator (ANT).

Age-related changes of skeletal muscle metabolic response to contraction are also sex-dependent.

Mitochondrial Targeted Interventions for Aging.

Signatures of Cysteine Oxidation on Muscle Structural and Contractile Proteins Are Associated with Physical Performance and Muscle Function in Older Adults: Study of Muscle, Mobility and Aging (SOMMA).

Lower muscle mitochondrial energetics is associated with greater phenotypic frailty in older women and men: the Study of Muscle, Mobility and Aging.

Skeletal Muscle Energetics Explain the Sex Disparity in Mobility Impairment in the Study of Muscle, Mobility and Aging.

Energetics and clinical factors for the time required to walk 400 m: The Study of Muscle, Mobility and Aging (SOMMA).

Signatures of cysteine oxidation on muscle structural and contractile proteins are associated with physical performance and muscle function in older adults: Study of Muscle, Mobility and Aging (SOMMA).

Childhood adverse life events and skeletal muscle mitochondrial function.

Role of Cardiorespiratory Fitness and Mitochondrial Oxidative Capacity in Reduced Walk Speed of Older Adults with Diabetes.

Older-aged C57BL/6 mice fed a diet high in saturated fat and sucrose for ten months show decreased resilience to aging.