Takahiro A. Kato

Plasma acetylcholine and nicotinic acid are correlated with focused preference for photographed females in depressed males: an economic game study.

Inhibitory effects of SSRIs on IFN-γ induced microglial activation through the regulation of intracellular calcium.

Development of 2-hour suicide intervention program among medical residents: first pilot trial.

Impact of biopsychosocial factors on psychiatric training in Japan and overseas: are psychiatrists oriented to mind, brain, or sociocultural issues?

Aripiprazole inhibits superoxide generation from phorbol-myristate-acetate (PMA)-stimulated microglia in vitro: implication for antioxidative psychotropic actions via microglia.

Does the 'hikikomori' syndrome of social withdrawal exist outside Japan? A preliminary international investigation.

Introducing the concept of modern depression in Japan; an international case vignette survey.

Minocycline modulates human social decision-making: possible impact of microglia on personality-oriented social behaviors.

Hikikomori as a possible clinical term in psychiatry: a questionnaire survey.

Nationwide survey of work environment, work-life balance and burnout among psychiatrists in Japan.

Are microglia minding us? Digging up the unconscious mind-brain relationship from a neuropsychoanalytic approach.

Minocycline, a microglial inhibitor, reduces 'honey trap' risk in human economic exchange.

Missing and Possible Link between Neuroendocrine Factors, Neuropsychiatric Disorders, and Microglia.

Undergraduate medical students' attitudes towards psychiatry: an international cross-sectional survey between India and Japan.

Pretreatment of aripiprazole and minocycline, but not haloperidol, suppresses oligodendrocyte damage from interferon-γ-stimulated microglia in co-culture model.

Neuron-glia interaction as a possible glue to translate the mind-brain gap: a novel multi-dimensional approach toward psychology and psychiatry.

Minocycline, a microglial inhibitor, diminishes terminal patients' delirium?

Brain-derived neurotrophic factor (BDNF) induces sustained intracellular Ca2+ elevation through the up-regulation of surface transient receptor potential 3 (TRPC3) channels in rodent microglia.

Direct induction of ramified microglia-like cells from human monocytes: dynamic microglial dysfunction in Nasu-Hakola disease.

Identification of the hikikomori syndrome of social withdrawal: Psychosocial features and treatment preferences in four countries.

Anti-allergic mechanisms of Japanese herbal medicine, yokukansan on mast cells.

The prevalence and correlates of severe social withdrawal in Hong Kong.

Microglial intracellular Ca(2+) signaling as a target of antipsychotic actions for the treatment of schizophrenia.

Clinical utility of neuronal cells directly converted from fibroblasts of patients for neuropsychiatric disorders: studies of lysosomal storage diseases and channelopathy.

Relationship between trusting behaviors and psychometrics associated with social network and depression among young generation: a pilot study.

[Redox and microglia in the pathophysiology of schizophrenia].

Psychopathology associated with social withdrawal: Idiopathic and comorbid presentations.

MK-801 treatment affects glycolysis in oligodendrocytes more than in astrocytes and neuronal cells: insights for schizophrenia.

Introducing directly induced microglia-like (iMG) cells from fresh human monocytes: a novel translational research tool for psychiatric disorders.

Effectiveness of suicide prevention gatekeeper-training for university administrative staff in Japan.

Multidimensional anatomy of 'modern type depression' in Japan: A proposal for a different diagnostic approach to depression beyond the DSM-5.

A patient with Alzheimer's disease complicated by elderly-onset Cushing's syndrome who had undergone surgical treatment for adrenocorticotropic hormone-independent macronodular adrenal hyperplasia.

TNF-α from hippocampal microglia induces working memory deficits by acute stress in mice.

Boundless syndromes in modern society: An interconnected world producing novel psychopathology in the 21st century.

A 39-Year-Old "Adultolescent": Understanding Social Withdrawal in Japan.

Internet addiction and self-evaluated attention-deficit hyperactivity disorder traits among Japanese college students.

Aripiprazole inhibits polyI:C-induced microglial activation possibly via TRPM7.

New game software (Pokémon Go) may help youth with severe social withdrawal, hikikomori.

Can Pokémon GO rescue shut-ins (hikikomori) from their isolated world?

Plasma Metabolites Predict Severity of Depression and Suicidal Ideation in Psychiatric Patients-A Multicenter Pilot Analysis.

Microglia-derived neuregulin expression in psychiatric disorders.

Microglial CD206 Gene Has Potential as a State Marker of Bipolar Disorder.

Comparison of treatment patterns in schizophrenia between China and Japan (2001-2009).

Progressive brain atrophy and cognitive decline along with multiple episodes of delirium.

Effect of Excessive Coffee Consumption on the Clinical Course of a Patient With Bipolar Disorder: A Case Report and Literature Review.

Development of a 2-h suicide prevention program for medical staff including nurses and medical residents: A two-center pilot trial.

[Translational Research on Neuropsychiatric Disorders: Focusing on Microglia Hypothesis].

Fibromyalgia and microglial TNF-α: Translational research using human blood induced microglia-like cells.

Dysregulated gene expressions of MEX3D, FOS and BCL2 in human induced-neuronal (iN) cells from NF1 patients: a pilot study.

Does hikikomori (severe social withdrawal) exist among young people in urban areas of China?

Modern-Type Depression as an "Adjustment" Disorder in Japan: The Intersection of Collectivistic Society Encountering an Individualistic Performance-Based System.

Donepezil suppresses intracellular Ca mobilization through the PI3K pathway in rodent microglia.

Hikikomori: experience in Japan and international relevance.

Second-Generation Antipsychotic-Induced Hypoglycemia.

Blood biomarkers of Hikikomori, a severe social withdrawal syndrome.

p66Shc Signaling Mediates Diabetes-Related Cognitive Decline.

Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naïve patients with major depressive disorder: An exploratory pilot case-control study.

FTD with catatonia-like signs that temporarily resolved with zolpidem.

Early-onset epileptic encephalopathy and severe developmental delay in an association with de novo double mutations in and .

Lamotrigine Rechallenge in Treatment-Resistant Bipolar Disorder.

Is a Socio-Cultural Analysis of Depressive Disorders a Matter of Concern? Response to Kaiya.

Does LINE addiction exist? Potential concerns about Japan's most popular form of social media on smartphones.

Harnessing Social Media to Explore Youth Social Withdrawal in Three Major Cities in China: Cross-Sectional Web Survey.

Prevalence rate of Internet addiction among Japanese college students: Two cross-sectional studies and reconsideration of cut-off points of Young's Internet Addiction Test in Japan.

Development and validation of the 25-item Hikikomori Questionnaire (HQ-25).

Neuron-related blood inflammatory markers as an objective evaluation tool for major depressive disorder: An exploratory pilot case-control study.

Cushing's Syndrome and Psychosis: A Case Report and Literature Review.

Development of MHFA-based 2-h educational program for early intervention in depression among office workers: A single-arm pilot trial.

Smartphone Addiction in Japanese College Students: Usefulness of the Japanese Version of the Smartphone Addiction Scale as a Screening Tool for a New Form of Internet Addiction.

Suicide and Microglia: Recent Findings and Future Perspectives Based on Human Studies.

Development and validation of the 22-item Tarumi's Modern-Type Depression Trait Scale: Avoidance of Social Roles, Complaint, and Low Self-Esteem (TACS-22).

Hikikomori : Multidimensional understanding, assessment, and future international perspectives.

Cannabis use correlates with aggressive behavior and long-acting injectable antipsychotic treatment in Asian patients with schizophrenia.

Clarifying Deeper Psychological Characteristics of Hikikomori Using the Rorschach Comprehensive System: A Pilot Case-Control Study.

Cuprizone-treated mice, a possible model of schizophrenia, highlighting the simultaneous abnormalities of GABA, serine and glycine in hippocampus.

Internet Addiction, Smartphone Addiction, and Hikikomori Trait in Japanese Young Adult: Social Isolation and Social Network.

Hikikomori Phenomenon in East Asia: Regional Perspectives, Challenges, and Opportunities for Social Health Agencies.

Modeling of the Bipolar Disorder and Schizophrenia Using Patient-Derived Induced Pluripotent Stem Cells with Copy Number Variations of 5 and .

Antidepressant effect of the translocator protein antagonist ONO-2952 on mouse behaviors under chronic social defeat stress.

The Self-Construal Scale: A Potential Tool for Predicting Subjective Well-Being of Individuals With Autism Spectrum Disorder.

Improvement Of Frontal Lobe Dysfunction And White Matter Integrity By rTMS In Treatment-Resistant Depression.

Defining pathological social withdrawal: proposed diagnostic criteria for hikikomori.

Development of 5-day hikikomori intervention program for family members: A single-arm pilot trial.

Network analysis of the depressive symptom profiles in Asian patients with depressive disorders: Findings from the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD).

Internet society, internet addiction, and pathological social withdrawal: the chicken and egg dilemma for internet addiction and hikikomori.

Involvement of exchange protein directly activated by cAMP and tumor progression locus 2 in IL-1β production in microglial cells following activation of β-adrenergic receptors.

Changes in interleukin-1 beta induced by rTMS are significantly correlated with partial improvement of cognitive dysfunction in treatment-resistant depression: a pilot study.

Patterns of long acting injectable antipsychotic use and associated clinical factors in schizophrenia among 15 Asian countries and region.

Dyskinesia is most centrally situated in an estimated network of extrapyramidal syndrome in Asian patients with schizophrenia: findings from research on Asian psychotropic prescription patterns for antipsychotics.

Forced social isolation due to COVID-19 and consequent mental health problems: Lessons from hikikomori.

Social withdrawal in major depressive disorder: a case-control study of hikikomori in japan.

Coprescription of mood stabilizers in schizophrenia, dosing, and clinical correlates: An international study.

Autism spectrum conditions in hikikomori: A pilot case-control study.

Kynurenic acid is a potential overlapped biomarker between diagnosis and treatment response for depression from metabolome analysis.

Forskolin rapidly enhances neuron-like morphological change of directly induced-neuronal cells from neurofibromatosis type 1 patients.

Personality classification enhances blood metabolome analysis and biotyping for major depressive disorders: two-species investigation.

GNAO1 organizes the cytoskeletal remodeling and firing of developing neurons.

Involvement of microglia in disturbed fear memory regulation: Possible microglial contribution to the pathophysiology of posttraumatic stress disorder.

Beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model.

Future perspectives of robot psychiatry: can communication robots assist psychiatric evaluation in the COVID-19 pandemic era?

Use of a tele-operated robot to increase sociability in individuals with autism spectrum disorder who display Hikikomori.

ProBDNF induces sustained elevation of intracellular Ca possibly mediated by TRPM7 channels in rodent microglial cells.

Impaired neurite development and mitochondrial dysfunction associated with calcium accumulation in dopaminergic neurons differentiated from the dental pulp stem cells of a patient with metatropic dysplasia.

The changes in kynurenine metabolites induced by rTMS in treatment-resistant depression: A pilot study.

Effectiveness of suicide prevention gatekeeper training for university teachers in Japan.

Psychodynamic group psychotherapy for hikikomori: The case of a socially withdrawn male with schizoaffective disorder.

CD206 Expression in Induced Microglia-Like Cells From Peripheral Blood as a Surrogate Biomarker for the Specific Immune Microenvironment of Neurosurgical Diseases Including Glioma.

International experience of hikikomori (prolonged social withdrawal) and its relevance to psychiatric research.

Optimized protocol for the extraction of RNA and DNA from frozen whole blood sample stored in a single EDTA tube.

A Call for a Rational Polypharmacy Policy: International Insights From Psychiatrists.

Network Analysis-Based Disentanglement of the Symptom Heterogeneity in Asian Patients with Schizophrenia: Findings from the Research on Asian Psychotropic Prescription Patterns for Antipsychotics.

Prescription Patterns for Bipolar Disorder in Asian Countries: Findings from Research on Asian Prescription Pattern-Bipolar Disorder.

Low-Density Lipoprotein Cholesterol Is a Possible Blood Biomarker of Schizoid Personality Traits among Females.

Psychological Traits of Patients With Depression Comorbid With Chronic Pain: Are Complaint and Competitive Tendency Related to Pain?

Dosing of Mood Stabilizers for Bipolar Disorder Patients in the Research on Asian Psychotropic Prescription Patterns Consortium Study.

Changes in the metabolites of cerebrospinal fluid induced by rTMS in treatment-resistant depression: A pilot study.

Cross-Disorder Analysis of Genic and Regulatory Copy Number Variations in Bipolar Disorder, Schizophrenia, and Autism Spectrum Disorder.

Hikikomori and modern-type depression in Italy: A new phenotypical trans-cultural characterization?

Machine Learning Algorithm-Based Prediction Model for the Augmented Use of Clozapine with Electroconvulsive Therapy in Patients with Schizophrenia.

Dopamine-related oxidative stress and mitochondrial dysfunction in dopaminergic neurons differentiated from deciduous teeth-derived stem cells of children with Down syndrome.

Blood metabolic signatures of hikikomori, pathological social withdrawal.

Mitochondrial Calcium-Triggered Oxidative Stress and Developmental Defects in Dopaminergic Neurons Differentiated from Deciduous Teeth-Derived Dental Pulp Stem Cells with MFF Insufficiency.

A Machine-Learning-Algorithm-Based Prediction Model for Psychotic Symptoms in Patients with Depressive Disorder.

Risk factors of hikikomori among office workers during the COVID-19 pandemic: A prospective online survey.

A network analysis of problematic smartphone use in Japanese young adults.

Sex-differences in hikikomori traits as predictors of problematic internet use in Italian university students.

Personality traits of female vocational school students in Japan with smartphone addiction with comorbid modern-type depression traits.

One month version of Hikikomori Questionnaire-25 (HQ-25M): Development and initial validation.

A case of bipolar disorder with AIF1 (coding gene of Iba-1) deletion: A pilot in vitro analysis using blood-derived microglia-like cells.

Preliminary analysis of hippocampus synaptic apoptosis and microglial phagocytosis induced by severe restraint stress.

The factor structure of extrapyramidal symptoms evaluated using the Drug-Induced Extrapyramidal Symptoms Scale in patients with schizophrenia: Results from the 2016 REAP AP-4 study.

Editorial: The development of biomarkers in psychiatry.

3-day intervention program for family members of hikikomori sufferers: A pilot randomized controlled trial.

Interferon signaling and hypercytokinemia-related gene expression in the blood of antidepressant non-responders.

Shank3a/b isoforms regulate the susceptibility to seizures and thalamocortical development in the early postnatal period of mice.

Clinical Usefulness of a Short Version of the Internet Addiction Test to Screen for Probable Internet Addiction in Adolescents with Autism Spectrum Disorder.

Pathological social withdrawal in autism spectrum disorder: A case control study of hikikomori in Japan.

Clozapine Use for Bipolar Disorder: An Asian Psychotropic Prescription Patterns Consortium Study.

Clinical use of mood stabilizers beyond treatment for bipolar disorder: The REAP-MS study.

High-sensitivity C-reactive protein and bilirubin as possible biomarkers for hikikomori in depression: A case-control study.

Hikikomori-like social withdrawal: An Italian case report.

Corrigendum to "Clinical use of mood stabilizers beyond treatment for bipolar disorder: The REAP-MS study" [Asian J. Psychiatry 85 (2023) 103613].

Hikikomori: A perspective from bibliometric analysis.

Ameliorative effects of Fingolimod (FTY720) on microglial activation and psychosis-related behavior in short term cuprizone exposed mice.

Analyzing changes in help-seeking from mental and physical health professionals during COVID-19 in Japan.

Heterogeneity and mitochondrial vulnerability configurate the divergent immunoreactivity of human induced microglia-like cells.

Angiogenic and inflammatory responses in human induced microglia-like (iMG) cells from patients with Moyamoya disease.

The Hikikomori Diagnostic Evaluation (HiDE): a proposal for a structured assessment of pathological social withdrawal.

Effects of melatonin on dopaminergic neuron development via IP3-mediated mitochondrial Ca regulation in autism spectrum disorder.

Hikikomori and gaming disorder tendency: A case-control online survey for nonworking adults.

Editorial: Hikikomori: an international perspective on assessment, treatment, and community intervention.

Heterogeneity of gaming disorder: A clinically-based typology for developing personalized interventions.

TRPV4-mediated Ca deregulation causes mitochondrial dysfunction via the AKT/α-synuclein pathway in dopaminergic neurons.

Development of depression assessment tools using humanoid robots -Can tele-operated robots talk with depressive persons like humans?

Pharmacoepidemiology and Clinical Correlates of Lithium Treatment for Bipolar Disorder in Asia.

Could the Construct of Modern-Type Depression Predict Internet Gaming Disorder in Italian Video Gamers? A Case-Control Study.

Shifting the paradigm of social withdrawal: a new era of coexisting pathological and non-pathological hikikomori.

Unexpected risk factors of pathological hikikomori during the COVID-19 pandemic among working adults initially without social isolation: A longitudinal online survey.

Predominant affective temperaments in depressive patients with severe social withdrawal.

Does childhood maltreatment affect hikikomori via traits of modern-type depression?

ATP1A3 regulates protein synthesis for mitochondrial stability under heat stress.

Analysis of Antipsychotic Dosage in Patients With Tardive Dyskinesia: A Case-Control Study Using the Claims Database of the Corporate Health Insurance Association.

An N-terminal and ankyrin repeat domain interactome of Shank3 identifies the protein complex with the splicing regulator Nono in mice.

Gnao1 is a molecular switch that regulates the Rho signaling pathway in differentiating neurons.