Institute of Computational Biology,
German Research Center for Environmental Health,
Institute of Computational Biology, German Research Center for Environmental Health
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Alternative Splicing Signatures in RNA-seq Data: Percent Spliced in (PSI).
Current protocols in human genetics Oct, 2015 | Pubmed ID: 26439713
Meta-analysis identifies seven susceptibility loci involved in the atopic march.
Nature communications Nov, 2015 | Pubmed ID: 26542096
A roadmap of constitutive NF-κB activity in Hodgkin lymphoma: Dominant roles of p50 and p52 revealed by genome-wide analyses.
Genome medicine Mar, 2016 | Pubmed ID: 26988706
Comparison of Cox Model Methods in A Low-dimensional Setting with Few Events.
Genomics, proteomics & bioinformatics Aug, 2016 | Pubmed ID: 27224515
Principles of microRNA Regulation Revealed Through Modeling microRNA Expression Quantitative Trait Loci.
Genetics Aug, 2016 | Pubmed ID: 27260304
52 Genetic Loci Influencing Myocardial Mass.
Journal of the American College of Cardiology Sep, 2016 | Pubmed ID: 27659466
Epigenetics and Control of RNAs.
Methods in molecular biology (Clifton, N.J.) , 2017 | Pubmed ID: 27933526
Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function.
PloS one , 2017 | Pubmed ID: 28158196
Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1.
Nature neuroscience Aug, 2017 | Pubmed ID: 28628102
Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy.
Genome biology Sep, 2017 | Pubmed ID: 28903782
Cadm2 regulates body weight and energy homeostasis in mice.
Molecular metabolism Feb, 2018 | Pubmed ID: 29217450
Using Gene Expression to Annotate Cardiovascular GWAS Loci.
Frontiers in cardiovascular medicine , 2018 | Pubmed ID: 29922679
Efficient Parameter Estimation Enables the Prediction of Drug Response Using a Mechanistic Pan-Cancer Pathway Model.
Cell systems Dec, 2018 | Pubmed ID: 30503647
Systems Genetics Approaches in Rat Identify Novel Genes and Gene Networks Associated With Cardiac Conduction.
Journal of the American Heart Association Nov, 2018 | Pubmed ID: 30608189
Association of Human Promoter Variants with the Occurrence of Knee-Osteoarthritis in a Case Control Association Study.
International journal of molecular sciences Mar, 2019 | Pubmed ID: 30893847
Inflammatory macrophage memory in nonsteroidal anti-inflammatory drug-exacerbated respiratory disease.
The Journal of allergy and clinical immunology Feb, 2021 | Pubmed ID: 32540397
Identification and characterization of distinct brown adipocyte subtypes in C57BL/6J mice.
Life science alliance Jan, 2021 | Pubmed ID: 33257475
scPower accelerates and optimizes the design of multi-sample single cell transcriptomic studies.
Nature communications Nov, 2021 | Pubmed ID: 34785648
Polygenic risk for coronary artery disease in the Scottish and English population.
BMC cardiovascular disorders Dec, 2021 | Pubmed ID: 34876023
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function.
Nature genetics Jan, 2022 | Pubmed ID: 34980917
Tissue-specific multi-omics analysis of atrial fibrillation.
Nature communications Jan, 2022 | Pubmed ID: 35064145
Pathogenic variants damage cell composition and single cell transcription in cardiomyopathies.
Science (New York, N.Y.) Aug, 2022 | Pubmed ID: 35926050
Probing cell identity hierarchies by fate titration and collision during direct reprogramming.
Molecular systems biology Sep, 2022 | Pubmed ID: 36106915
A proteome-scale map of the SARS-CoV-2-human contactome.
Nature biotechnology Jan, 2023 | Pubmed ID: 36217029
Network reconstruction for trans acting genetic loci using multi-omics data and prior information.
Genome medicine Nov, 2022 | Pubmed ID: 36344995
DeepSom: a CNN-based approach to somatic variant calling in WGS samples without a matched normal.
Bioinformatics (Oxford, England) Jan, 2023 | Pubmed ID: 36637201
Predictive model of transcriptional elongation control identifies trans regulatory factors from chromatin signatures.
Nucleic acids research Feb, 2023 | Pubmed ID: 36727445
Machine learning reveals STAT motifs as predictors for GR-mediated gene repression.
Computational and structural biotechnology journal , 2023 | Pubmed ID: 36879886
Identification of genetic variants that impact gene co-expression relationships using large-scale single-cell data.
Genome biology Apr, 2023 | Pubmed ID: 37072791
Darier's disease exhibits a unique cutaneous microbial dysbiosis associated with inflammation and body malodour.
Microbiome Jul, 2023 | Pubmed ID: 37496039
An arrhythmogenic metabolite in atrial fibrillation.
Journal of translational medicine Aug, 2023 | Pubmed ID: 37620858
Correction: Darier's disease exhibits a unique cutaneous microbial dysbiosis associated with inflammation and body malodour.
Microbiome Sep, 2023 | Pubmed ID: 37705089
Speos: an ensemble graph representation learning framework to predict core gene candidates for complex diseases.
Nature communications Nov, 2023 | Pubmed ID: 37938585
Single-Cell Dissection of the Immune Response After Acute Myocardial Infarction.
Circulation. Genomic and precision medicine Jun, 2024 | Pubmed ID: 38752343
Multiomic analyses uncover immunological signatures in acute and chronic coronary syndromes.
Nature medicine Jun, 2024 | Pubmed ID: 38773340
Plasmacytoid dendritic cells control homeostasis of megakaryopoiesis.
Nature Jul, 2024 | Pubmed ID: 38987596
Differential Analysis of Protein-DNA Binding Using ChIP-Seq Data.
Methods in molecular biology (Clifton, N.J.) , 2024 | Pubmed ID: 39141230
Corinna Losert1,2,
Kami Pekayvaz3,4,
Viktoria Knottenberg3,4,
Leo Nicolai3,4,
Konstantin Stark3,4,
Matthias Heinig1,2,4
1Institute of Computational Biology, German Research Center for Environmental Health, Helmholtz Zentrum München,
2Department of Computer Science, TUM School of Computation, Information and Technology, Technical University of Munich,
3, Medizinische Klinik und Poliklinik I University Hospital Ludwig-Maximilian University,
4, German Centre for Cardiovascular Research (DZHK), partner site Munich Heart Alliance