David Hawke

Expression and purification of the angiogenesis inhibitor 16-kDa prolactin fragment from insect cells.

Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation.

Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro.

A circulating ligand for galectin-3 is a haptoglobin-related glycoprotein elevated in individuals with colon cancer.

Developing an understanding of proteomics: an introduction to biological mass spectrometry.

Diagnostic protein discovery using liquid chromatography/mass spectrometry for proteolytic peptide targeting.

A role for cell-cycle-regulated histone H3 lysine 56 acetylation in the DNA damage response.

The Set1 methyltransferase opposes Ipl1 aurora kinase functions in chromosome segregation.

Serum amyloid A as a tumor marker in sera of nude mice with orthotopic human pancreatic cancer and in plasma of patients with pancreatic cancer.

Proteomic analysis of nipple aspirate fluid from women with early-stage breast cancer using isotope-coded affinity tags and tandem mass spectrometry reveals differential expression of vitamin D binding protein.

Tyrosine phosphorylation controls PCNA function through protein stability.

A method for the isolation of blocked N-terminal peptides.

Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity.

Proteomics-based identification of proteins secreted in apical surface fluid of squamous metaplastic human tracheobronchial epithelial cells cultured by three-dimensional organotypic air-liquid interface method.

Stimulation of lung innate immunity protects against lethal pneumococcal pneumonia in mice.

Immunologic glycosphingolipidomics and NKT cell development in mouse thymus.

Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis.

FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST.

Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues.

EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin.

From combinatorial peptide selection to drug prototype (I): targeting the vascular endothelial growth factor receptor pathway.

Evaluation of changes in serum protein profiles during neoadjuvant chemotherapy in HER2-positive breast cancer using an LC-MALDI-TOF/MS procedure.

Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells.

The ABRF Proteomics Research Group studies: educational exercises for qualitative and quantitative proteomic analyses.

Identification and validation of SRC and phospho-SRC family proteins in circulating mononuclear cells as novel biomarkers for pancreatic cancer.

PMLRARα binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo.

Ras-induced and extracellular signal-regulated kinase 1 and 2 phosphorylation-dependent isomerization of protein tyrosine phosphatase (PTP)-PEST by PIN1 promotes FAK dephosphorylation by PTP-PEST.

AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis.

Characterization of a human 12/15-lipoxygenase promoter variant associated with atherosclerosis identifies vimentin as a promoter binding protein.

PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis.

Phosphopeptide characterization by mass spectrometry using reversed-phase supports for solid-phase β-elimination/Michael addition.

Binding partners for curcumin in human schwannoma cells: biologic implications.

Glioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2.

Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1.

Lack of iGb3 and Isoglobo-Series Glycosphingolipids in Pig Organs Used for Xenotransplantation: Implications for Natural Killer T-Cell Biology.

C-Terminal Protein Characterization by Mass Spectrometry using Combined Micro Scale Liquid and Solid-Phase Derivatization.