John H. Zhang

Hyperbaric oxygen therapy and cerebral ischemia: neuroprotective mechanisms.

Neuroprotective effect of volatile anesthetic agents: molecular mechanisms.

Cerebral vasospasm following subarachnoid hemorrhage: time for a new world of thought.

The effect of 2-methoxyestradiol, a HIF-1 alpha inhibitor, in global cerebral ischemia in rats.

Oxidative stress after subarachnoid hemorrhage in gp91phox knockout mice.

The hyperbaric oxygen preconditioning-induced brain protection is mediated by a reduction of early apoptosis after transient global cerebral ischemia.

A new grading system evaluating bleeding scale in filament perforation subarachnoid hemorrhage rat model.

Posterior circulation stroke and animal models.

NgR acts as an inhibitor to axonal regeneration in adults.

Matrix metalloproteinase inhibition attenuates brain edema in an in vivo model of surgically-induced brain injury.

Mechanism of ischemic tolerance induced by hyperbaric oxygen preconditioning involves upregulation of hypoxia-inducible factor-1alpha and erythropoietin in rats.

Mechanism of hyperbaric oxygen preconditioning in neonatal hypoxia-ischemia rat model.

[Basic research and treatment for cerebral vasospasm after subarachnoid hemorrhage: the present and future prospects].

Melatonin decreases mortality following severe subarachnoid hemorrhage.

Repetitive hyperbaric oxygen exposures enhance sensitivity to convulsion by upregulation of eNOS and nNOS.

Role of histamine in brain protection in surgical brain injury in mice.

Hyperbaric oxygen preconditioning induces tolerance against brain ischemia-reperfusion injury by upregulation of antioxidant enzymes in rats.

Up-regulated HIF-1alpha is involved in the hypoxic tolerance induced by hyperbaric oxygen preconditioning.

Rosiglitazone, a PPAR gamma agonist, attenuates inflammation after surgical brain injury in rodents.

Surgical brain injury: prevention is better than cure.

Electro-stimulation of cerebellar fastigial nucleus (FNS) improves axonal regeneration.

Dual effects of melatonin on oxidative stress after surgical brain injury in rats.

HIF-1alpha inhibition ameliorates neonatal brain injury in a rat pup hypoxic-ischemic model.

Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia rat model.

Reduced brain injury in CD18-deficient mice after experimental intracerebral hemorrhage.

Hyperbaric oxygen preconditioning promotes angiogenesis in rat liver after partial hepatectomy.

Chinese neurosurgery research.

Dr Chung-Cheng Wang and Beijing Neurosurgical Institute.

The effect of ecdysterone on cerebral vasospasm following experimental subarachnoid hemorrhage in vitro and in vivo.

Simvastatin attenuation of cerebral vasospasm after subarachnoid hemorrhage in rats via increased phosphorylation of Akt and endothelial nitric oxide synthase.

Hyperbaric oxygen preconditioning alleviates myocardial ischemic injury in rats.

Risk factors for short-term mortality from carbon monoxide poisoning treated with hyperbaric oxygen.

The neurosurgical role of epigenome.

Prodeath or prosurvival: two facets of hypoxia inducible factor-1 in perinatal brain injury.

Neuroprotective effects of hydrogen saline in neonatal hypoxia-ischemia rat model.

Subarachnoid hemorrhage: is it time for a new direction?

Therapeutic application of gene silencing MMP-9 in a middle cerebral artery occlusion-induced focal ischemia rat model.

Experimental models of subarachnoid hemorrhage for studies of cerebral vasospasm.

Normoxic induction of cerebral HIF-1alpha by acetazolamide in rats: role of acidosis.

Early inhibition of HIF-1alpha with small interfering RNA reduces ischemic-reperfused brain injury in rats.

Hydrogen gas is ineffective in moderate and severe neonatal hypoxia-ischemia rat models.

Hyperbaric oxygen preconditioning attenuates early apoptosis after spinal cord ischemia in rats.

Thrombin inhibition by argatroban ameliorates early brain injury and improves neurological outcomes after experimental subarachnoid hemorrhage in rats.

Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats.

Molecular neurosciences.

Granulocyte colony-stimulating factor protects the brain against experimental stroke via inhibition of apoptosis and inflammation.

Effect of gap junction inhibition on intracerebral hemorrhage-induced brain injury in mice.

The effects of nicotinamide adenine dinucleotide on intracerebral hemorrhage-induced brain injury in mice.

Glibenclamide improves neurological function in neonatal hypoxia-ischemia in rats.

Hydrogen-rich saline protects against intestinal ischemia/reperfusion injury in rats.

Effects of melatonin in early brain injury following subarachnoid hemorrhage.

Matrix metalloproteinase inhibition attenuates brain edema after surgical brain injury.

The antioxidant effects of melatonin in surgical brain injury in rats.

HIF-1 alpha inhibition ameliorates neonatal brain damage after hypoxic-ischemic injury.

Role of interleukin-1beta in early brain injury after subarachnoid hemorrhage in mice.

Assessing functional outcomes following intracerebral hemorrhage in rats.

Hydrogen-rich saline protects myocardium against ischemia/reperfusion injury in rats.

Cyclo-oxygenase-2 mediates hyperbaric oxygen preconditioning-induced neuroprotection in the mouse model of surgical brain injury.

Matrix metalloproteinase-9 potentiates early brain injury after subarachnoid hemorrhage.

Matrix metalloproteinases inhibition provides neuroprotection against hypoxia-ischemia in the developing brain.

The Great Chinese Famine leads to shorter and overweight females in Chongqing Chinese population after 50 years.

Reduced matrix metalloproteinase-9 activity and cell death after global ischemia in the brain preconditioned with hyperbaric oxygen.

The effects of tetrahydrobiopterin on intracerebral hemorrhage-induced brain injury in mice.

Hyperbaric oxygen preconditioning reduces postoperative brain edema and improves neurological outcomes after surgical brain injury.

Protective effects of recombinant osteopontin on early brain injury after subarachnoid hemorrhage in rats.

Caspase-1 inhibitor prevents neurogenic pulmonary edema after subarachnoid hemorrhage in mice.

Activation of sphingosine 1-phosphate receptor-1 by FTY720 is neuroprotective after ischemic stroke in rats.

Maternal hypoxia increases the activity of MMPs and decreases the expression of TIMPs in the brain of neonatal rats.

Role of gap junctions in early brain injury following subarachnoid hemorrhage.

Cyclooxygenase-2 inhibition provides lasting protection against neonatal hypoxic-ischemic brain injury.

Ten-year clinical epidemiological trends of intracerebral hemorrhage in Chongqing, China.

Hyperbaric oxygen therapy improves early posttransplant islet function.

Suppression of hypoxia-inducible factor-1alpha and its downstream genes reduces acute hyperglycemia-enhanced hemorrhagic transformation in a rat model of cerebral ischemia.

Hydrogen-rich saline improves memory function in a rat model of amyloid-beta-induced Alzheimer's disease by reduction of oxidative stress.

Protective effect of melatonin upon neuropathology, striatal function, and memory ability after intracerebral hemorrhage in rats.

Hydrogen-rich saline protects against spinal cord injury in rats.

Sulforaphane protects brains against hypoxic-ischemic injury through induction of Nrf2-dependent phase 2 enzyme.

Long-term evaluation of granulocyte-colony stimulating factor on hypoxic-ischemic brain damage in infant rats.

Isoflurane posttreatment reduces neonatal hypoxic-ischemic brain injury in rats by the sphingosine-1-phosphate/phosphatidylinositol-3-kinase/Akt pathway.

Saturated hydrogen saline protects the lung against oxygen toxicity.

Mechanisms of osteopontin-induced stabilization of blood-brain barrier disruption after subarachnoid hemorrhage in rats.

Down-regulation of Nogo receptor promotes functional recovery by enhancing axonal connectivity after experimental stroke in rats.

Heat shock protein 70 upregulation by geldanamycin reduces brain injury in a mouse model of intracerebral hemorrhage.

Vascular adhesion protein-1 inhibition provides antiinflammatory protection after an intracerebral hemorrhagic stroke in mice.

Characterization of the brain injury, neurobehavioral profiles, and histopathology in a rat model of cerebellar hemorrhage.

Bidirectional influences of acetazolamide on central nervous system oxygen toxicity of rats.

Lentivirus-mediated transfer of MMP-9 shRNA provides neuroprotection following focal ischemic brain injury in rats.

The microRNAs: Small size, big value,….

Recombinant osteopontin in cerebral vasospasm after subarachnoid hemorrhage.

Advances in experimental subarachnoid hemorrhage.

Apoptotic mechanisms for neuronal cells in early brain injury after subarachnoid hemorrhage.

Immunological response in early brain injury after SAH.

Mechanisms of early brain injury after SAH: matrix metalloproteinase 9.

Tyrosine phosphatase inhibition attenuates early brain injury after subarachnoid hemorrhage in rats.

Protection of minocycline on early brain injury after subarachnoid hemorrhage in rats.

Role of osteopontin in early brain injury after subarachnoid hemorrhage in rats.

Matrix metalloproteinase 9 inhibition reduces early brain injury in cortex after subarachnoid hemorrhage.

Mitogen-activated protein kinases in cerebral vasospasm after subarachnoid hemorrhage: a review.

PKGIα inhibits the proliferation of cerebral arterial smooth muscle cell induced by oxyhemoglobin after subarachnoid hemorrhage.

Expression and role of COMT in a rat subarachnoid hemorrhage model.

Perimesencephalic subarachnoid hemorrhage: risk factors, clinical presentations, and outcome.

Non-aneurysm subarachnoid hemorrhage in young adults.

Cardiac damage after subarachnoid hemorrhage.

Analysis on death-associated factors of patients with subarachnoid hemorrhage during hospitalization.

Effect of weekend admission on in-hospital mortality after subarachnoid hemorrhage in Chongqing China.

The correlation between COMT gene polymorphism and early cerebral vasospasm after subarachnoid hemorrhage.

Fever increased in-hospital mortality after subarachnoid hemorrhage.

Subarachnoid hemorrhage in old patients in Chongqing China.

The role of apolipoprotein e in the pathological events following subarachnoid hemorrhage: a review.

Mechanisms of statin treatment in cerebral vasospasm.

Effect of recombinant osteopontin on cerebral vasospasm after subarachnoid hemorrhage in rats.

Adenosine A3 receptor agonist reduces early brain injury in subarachnoid haemorrhage.

Metamorphosis of subarachnoid hemorrhage research: from delayed vasospasm to early brain injury.

Cyclooxygenase-2 mediates hyperbaric oxygen preconditioning in the rat model of transient global cerebral ischemia.

Comparison Evans Blue injection routes: Intravenous versus intraperitoneal, for measurement of blood-brain barrier in a mice hemorrhage model.

Remote limb ischemic postconditioning protects against neonatal hypoxic-ischemic brain injury in rat pups by the opioid receptor/Akt pathway.

Preservation of tropomyosin-related kinase B (TrkB) signaling by sodium orthovanadate attenuates early brain injury after subarachnoid hemorrhage in rats.

Hydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity.

Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-κB activation in a rat model of amyloid-beta-induced Alzheimer's disease.

Arginine-vasopressin V1a receptor inhibition improves neurologic outcomes following an intracerebral hemorrhagic brain injury.

Osteopontin reduced hypoxia-ischemia neonatal brain injury by suppression of apoptosis in a rat pup model.

Brain irradiation improves focal cerebral ischemia recovery in aged rats.

Isoflurane posttreatment reduces brain injury after an intracerebral hemorrhagic stroke in mice.

Resolving the Negative Data Publication Dilemma in Translational Stroke Research.

Sampling of CSF via the Cisterna Magna and Blood Collection via the Heart Affects Brain Water Content in a Rat SAH Model.

Tissue inhibitor of matrix metalloproteinase-1 mediates erythropoietin-induced neuroprotection in hypoxia ischemia.

History of preclinical models of intracerebral hemorrhage.

Comparison of different preclinical models of intracerebral hemorrhage.

Cerebral amyloid angiopathy-related microhemorrhages in Alzheimer's disease: a review of investigative animal models.

The postpartum period of pregnancy worsens brain injury and functional outcome after cerebellar hemorrhage in rats.

A novel preclinical model of germinal matrix hemorrhage using neonatal rats.

The evolving landscape of neuroinflammation after neonatal hypoxia-ischemia.

Subarachnoid hemorrhage causes pulmonary endothelial cell apoptosis and neurogenic pulmonary edema in mice.

The neuroprotective effects of cyclooxygenase-2 inhibition in a mouse model of aneurysmal subarachnoid hemorrhage.

NC1900, an arginine vasopressin analogue, fails to reduce brain edema and improve neurobehavioral deficits in an intracerebral hemorrhagic stroke mice model.

Geldanamycin reduced brain injury in mouse model of intracerebral hemorrhage.

Combined systemic thrombolysis with alteplase and early hyperbaric oxygen therapy in experimental embolic stroke in rats: relationship to functional outcome and reduction of structural damage.

Hydrogen inhalation is neuroprotective and improves functional outcomes in mice after intracerebral hemorrhage.

Post-treatment with SR49059 improves outcomes following an intracerebral hemorrhagic stroke in mice.

Neuroprotection by melatonin after germinal matrix hemorrhage in neonatal rats.

Endothelin receptor-A (ETa) inhibition fails to improve neonatal hypoxic-ischemic brain injury in rats.

FTY720 is neuroprotective and improves functional outcomes after intracerebral hemorrhage in mice.

Capsaicin pre-treatment provides neurovascular protection against neonatal hypoxic-ischemic brain injury in rats.

Effects of recombinant osteopontin on blood-brain barrier disruption after subarachnoid hemorrhage in rats.

Protective effect of hydrogen gas therapy after germinal matrix hemorrhage in neonatal rats.

Pretreatment with normobaric and hyperbaric oxygenation worsens cerebral edema and neurologic outcomes in a murine model of surgically induced brain injury.

Beneficial effect of hyperbaric oxygenation after neonatal germinal matrix hemorrhage.

Granulocyte colony-stimulating factor treatment provides neuroprotection in surgically induced brain injured mice.

Prostaglandin E2 EP1 receptor inhibition fails to provide neuroprotection in surgically induced brain-injured mice.

Mucosal tolerance to brain antigens preserves endogenous TGFβ-1 and improves neurological outcomes following experimental craniotomy.

Protective effects of hydrogen on fetal brain injury during maternal hypoxia.

Intracerebral hemorrhage and meteorological factors in Chongqing, in the southwest of China.

Timing pattern of onset in hypertensive intracerebral hemorrhage patients.

"Weekend effects" in patients with intracerebral hemorrhage.

Disparities in medical expenditure and outcomes among patients with intracranial hemorrhage associated with different insurance statuses in southwestern China.

Clinical analysis of electrolyte imbalance in thalamic hemorrhage patients within 24 h after admission.

Characteristics of pulse pressure parameters in acute intracerebral hemorrhage patients.

Electrocardiographic abnormalities in patients with intracerebral hemorrhage.

ECG change of acute subarachnoid hemorrhagic patients.

Characteristics of acute cerebral hemorrhage with regard to lipid metabolism and glycometabolism among different age groups.

Risk factors of early death in patients with hypertensive intracerebral hemorrhage during hospitalization.

Effects of early serum glucose levels on prognosis of patients with acute intracerebral hemorrhage.

Prognosis study of 324 cases with spontaneous intracerebral hemorrhage in Chongqing, China.

Endoscopic surgical treatment for pituitary apoplexy in three elderly patients over the age of 80.

Proton pump inhibitor prophylaxis increases the risk of nosocomial pneumonia in patients with an intracerebral hemorrhagic stroke.

Electrical stimulation of olfactory bulb downregulates RGMa expression after ischemia/reperfusion injury in rats.

Prolonged Exposure to Isoflurane Ameliorates Infarction Severity in the Rat Pup Model of Neonatal Hypoxia-Ischemia.

α7 nicotinic acetylcholine receptor agonist PNU-282987 attenuates early brain injury in a perforation model of subarachnoid hemorrhage in rats.

Minocycline improves functional outcomes, memory deficits, and histopathology after endovascular perforation-induced subarachnoid hemorrhage in rats.

Preoperative mucosal tolerance to brain antigens and a neuroprotective immune response following surgical brain injury.

Welcome to medical gas research.

Application of medical gases in the field of neurobiology.

Hyperbaric oxygen therapy promotes neurogenesis: where do we stand?

Hydrogen saline offers neuroprotection by reducing oxidative stress in a focal cerebral ischemia-reperfusion rat model.

The pacific chapter annual meeting of the undersea & hyperbaric medical society.

Hydrogen is neuroprotective against surgically induced brain injury.

Hydrogen saline treatment attenuates hyperoxia-induced retinopathy by inhibition of oxidative stress and reduction of VEGF expression.

Nanoerythropoietin is 10-times more effective than regular erythropoietin in neuroprotection in a neonatal rat model of hypoxia and ischemia.

CHOP silencing reduces acute brain injury in the rat model of subarachnoid hemorrhage.

Treatment with sodium orthovanadate reduces blood-brain barrier disruption via phosphatase and tensin homolog deleted on chromosome 10 (PTEN) phosphorylation in experimental subarachnoid hemorrhage.

PDGFR-α inhibition preserves blood-brain barrier after intracerebral hemorrhage.

α7 nicotinic acetylcholine receptor agonism confers neuroprotection through GSK-3β inhibition in a mouse model of intracerebral hemorrhage.

Sleep a therapeutic target for stroke?

Inhibition of Rho kinase by hydroxyfasudil attenuates brain edema after subarachnoid hemorrhage in rats.

Fibroblast growth factors preserve blood-brain barrier integrity through RhoA inhibition after intracerebral hemorrhage in mice.

Hydrogen gas ameliorates oxidative stress in early brain injury after subarachnoid hemorrhage in rats.

Role of HCN channels in neuronal hyperexcitability after subarachnoid hemorrhage in rats.

The importance of early brain injury after subarachnoid hemorrhage.

Isoflurane delays the development of early brain injury after subarachnoid hemorrhage through sphingosine-related pathway activation in mice.

Hyperbaric oxygen preconditioning attenuates hyperglycemia enhanced hemorrhagic transformation after transient MCAO in rats.

Rodent neonatal germinal matrix hemorrhage mimics the human brain injury, neurological consequences, and post-hemorrhagic hydrocephalus.

Effect of dexmedetomidine on brain edema and neurological outcomes in surgical brain injury in rats.

Hyperoxia preconditioning: the next frontier in neurology?

Etiology of stroke and choice of models.

Isoflurane attenuates blood-brain barrier disruption in ipsilateral hemisphere after subarachnoid hemorrhage in mice.

Role of the pituitary–adrenal axis in granulocyte-colony stimulating factor-induced neuroprotection against hypoxia–ischemia in neonatal rats.

Statin-induced T-lymphocyte modulation and neuroprotection following experimental subarachnoid hemorrhage.

The role of Volatile Anesthetics in Cardioprotection: a systematic review.

Targeting C/EBP homologous protein with siRNA attenuates cerebral vasospasm after experimental subarachnoid hemorrhage.

Liraglutide, a long-acting GLP-1 mimetic, and its metabolite attenuate inflammation after intracerebral hemorrhage.