Avi Gnatt

Intramolecular relationships in cholinesterases revealed by oocyte expression of site-directed and natural variants of human BCHE.

Excavations into the active-site gorge of cholinesterases.

Human acetylcholinesterase and butyrylcholinesterase are encoded by two distinct genes.

Aspartate-70 to glycine substitution confers resistance to naturally occurring and synthetic anionic-site ligands on in-ovo produced human butyrylcholinesterase.

Anionic site interactions in human butyrylcholinesterase disrupted by two single point mutations.

Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure.

Expression of alternatively terminated unusual human butyrylcholinesterase messenger RNA transcripts, mapping to chromosome 3q26-ter, in nervous system tumors.

Molecular cloning of human cholinesterase genes: potential applications in neurotoxicology.

Isolation and characterization of full-length cDNA clones coding for cholinesterase from fetal human tissues.

Molecular biological search for human genes encoding cholinesterases.

Use of synthetic oligodeoxynucleotide probes for the isolation of a human cholinesterase cDNA clone.

Testicular amplification and impaired transmission of human butyrylcholinesterase cDNA in transgenic mice.

Chimeric human cholinesterase. Identification of interaction sites responsible for recognition of acetyl- or butyrylcholinesterase-specific ligands.

Structure-function relationship studies in human cholinesterases reveal genomic origins for individual variations in cholinergic drug responses.

Site-directed mutagenesis of active site residues reveals plasticity of human butyrylcholinesterase in substrate and inhibitor interactions.

Evidence for a mediator cycle at the initiation of transcription.

Formation and crystallization of yeast RNA polymerase II elongation complexes.

Repeated tertiary fold of RNA polymerase II and implications for DNA binding.

Electron crystal structure of an RNA polymerase II transcription elongation complex.

Yeast RNA polymerase II at 5 A resolution.

Architecture of RNA polymerase II and implications for the transcription mechanism.

Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution.

Elongation by RNA polymerase II: structure-function relationship.

Cancer outcomes at the Hufeland (complementary/alternative medicine) klinik: a best-case series review.

Fcp1 directly recognizes the C-terminal domain (CTD) and interacts with a site on RNA polymerase II distinct from the CTD.

A Mediator-responsive form of metazoan RNA polymerase II.

Knockdown of TFIIS by RNA silencing inhibits cancer cell proliferation and induces apoptosis.

Differential blocking effects of the acetaldehyde-derived DNA lesion N2-ethyl-2'-deoxyguanosine on transcription by multisubunit and single subunit RNA polymerases.

Regulation of RUNX2 transcription factor-DNA interactions and cell proliferation by vitamin D3 (cholecalciferol) prohormone activity.

Functional association of Gdown1 with RNA polymerase II poised on human genes.

Transcriptional regulation by Pol II(G) involving mediator and competitive interactions of Gdown1 and TFIIF with Pol II.

Efficient reconstitution of transcription elongation complexes for single-molecule studies of eukaryotic RNA polymerase II.

Regulation of mammalian transcription by Gdown1 through a novel steric crosstalk revealed by cryo-EM.

Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides.