Department of Pharmacology & Experimental Therapeutics
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Intramolecular relationships in cholinesterases revealed by oocyte expression of site-directed and natural variants of human BCHE.
The EMBO journal Apr, 1992 | Pubmed ID: 1373381
Excavations into the active-site gorge of cholinesterases.
Trends in biochemical sciences Sep, 1992 | Pubmed ID: 1412713
Human acetylcholinesterase and butyrylcholinesterase are encoded by two distinct genes.
Cellular and molecular neurobiology Feb, 1991 | Pubmed ID: 2013062
Aspartate-70 to glycine substitution confers resistance to naturally occurring and synthetic anionic-site ligands on in-ovo produced human butyrylcholinesterase.
Journal of neuroscience research Dec, 1990 | Pubmed ID: 2079709
Anionic site interactions in human butyrylcholinesterase disrupted by two single point mutations.
The Journal of biological chemistry Dec, 1990 | Pubmed ID: 2249982
Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure.
Proceedings of the National Academy of Sciences of the United States of America Dec, 1990 | Pubmed ID: 2263619
Expression of alternatively terminated unusual human butyrylcholinesterase messenger RNA transcripts, mapping to chromosome 3q26-ter, in nervous system tumors.
Cancer research Apr, 1990 | Pubmed ID: 2317787
Molecular cloning of human cholinesterase genes: potential applications in neurotoxicology.
Progress in clinical and biological research , 1987 | Pubmed ID: 2963345
Isolation and characterization of full-length cDNA clones coding for cholinesterase from fetal human tissues.
Proceedings of the National Academy of Sciences of the United States of America Jun, 1987 | Pubmed ID: 3035536
Molecular biological search for human genes encoding cholinesterases.
Molecular neurobiology Spring-Summer, 1987 | Pubmed ID: 3077058
Use of synthetic oligodeoxynucleotide probes for the isolation of a human cholinesterase cDNA clone.
Journal of neuroscience research , 1986 | Pubmed ID: 3755763
Testicular amplification and impaired transmission of human butyrylcholinesterase cDNA in transgenic mice.
Human reproduction (Oxford, England) Feb, 1994 | Pubmed ID: 8027285
Chimeric human cholinesterase. Identification of interaction sites responsible for recognition of acetyl- or butyrylcholinesterase-specific ligands.
Journal of molecular biology Nov, 1993 | Pubmed ID: 8230213
Structure-function relationship studies in human cholinesterases reveal genomic origins for individual variations in cholinergic drug responses.
Progress in neuro-psychopharmacology & biological psychiatry Nov, 1993 | Pubmed ID: 8278601
Site-directed mutagenesis of active site residues reveals plasticity of human butyrylcholinesterase in substrate and inhibitor interactions.
Journal of neurochemistry Feb, 1994 | Pubmed ID: 8294937
Evidence for a mediator cycle at the initiation of transcription.
Proceedings of the National Academy of Sciences of the United States of America Jun, 1997 | Pubmed ID: 9177171
Formation and crystallization of yeast RNA polymerase II elongation complexes.
The Journal of biological chemistry Dec, 1997 | Pubmed ID: 9388221
Repeated tertiary fold of RNA polymerase II and implications for DNA binding.
Journal of molecular biology Jul, 1998 | Pubmed ID: 9665838
Electron crystal structure of an RNA polymerase II transcription elongation complex.
Cell Sep, 1999 | Pubmed ID: 10499796
Yeast RNA polymerase II at 5 A resolution.
Cell Sep, 1999 | Pubmed ID: 10499797
Architecture of RNA polymerase II and implications for the transcription mechanism.
Science (New York, N.Y.) Apr, 2000 | Pubmed ID: 10784442
Structural basis of transcription: an RNA polymerase II elongation complex at 3.3 A resolution.
Science (New York, N.Y.) Jun, 2001 | Pubmed ID: 11313499
Elongation by RNA polymerase II: structure-function relationship.
Biochimica et biophysica acta Sep, 2002 | Pubmed ID: 12213651
Cancer outcomes at the Hufeland (complementary/alternative medicine) klinik: a best-case series review.
Integrative cancer therapies Jun, 2005 | Pubmed ID: 15911928
Fcp1 directly recognizes the C-terminal domain (CTD) and interacts with a site on RNA polymerase II distinct from the CTD.
Proceedings of the National Academy of Sciences of the United States of America Nov, 2005 | Pubmed ID: 16301539
A Mediator-responsive form of metazoan RNA polymerase II.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2006 | Pubmed ID: 16769904
Knockdown of TFIIS by RNA silencing inhibits cancer cell proliferation and induces apoptosis.
BMC cancer , 2008 | Pubmed ID: 18474089
Differential blocking effects of the acetaldehyde-derived DNA lesion N2-ethyl-2'-deoxyguanosine on transcription by multisubunit and single subunit RNA polymerases.
The Journal of biological chemistry Oct, 2008 | Pubmed ID: 18669632
Regulation of RUNX2 transcription factor-DNA interactions and cell proliferation by vitamin D3 (cholecalciferol) prohormone activity.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research Apr, 2012 | Pubmed ID: 22189971
Functional association of Gdown1 with RNA polymerase II poised on human genes.
Molecular cell Jan, 2012 | Pubmed ID: 22244331
Transcriptional regulation by Pol II(G) involving mediator and competitive interactions of Gdown1 and TFIIF with Pol II.
Molecular cell Jan, 2012 | Pubmed ID: 22244332
Efficient reconstitution of transcription elongation complexes for single-molecule studies of eukaryotic RNA polymerase II.
Transcription May-Jun, 2012 | Pubmed ID: 22771949
Regulation of mammalian transcription by Gdown1 through a novel steric crosstalk revealed by cryo-EM.
The EMBO journal Aug, 2012 | Pubmed ID: 22850672
Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides.
PLoS pathogens , 2012 | Pubmed ID: 23166498
Karen F. Underwood1,
Maria T. Mochin1,
Jessica L. Brusgard2,
Moran Choe3,
Avi Gnatt4,
Antonino Passaniti3,5
1Greenebaum Cancer Center, University of Maryland School of Medicine,
2Program in Molecular Medicine, University of Maryland School of Medicine,
3Department of Biochemistry & Molecular Biology, University of Maryland School of Medicine,
4Department of Pharmacology & Experimental Therapeutics, University of Maryland School of Medicine,
5Department of Pathology and Biochemistry & Molecular Biology, University of Maryland School of Medicine
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