In-Hyun Park

Regulation of ribosomal S6 kinase 2 by mammalian target of rapamycin.

PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1.

IGF-II transcription in skeletal myogenesis is controlled by mTOR and nutrients.

Skeletal myocyte hypertrophy requires mTOR kinase activity and S6K1.

Mammalian target of rapamycin (mTOR) signaling is required for a late-stage fusion process during skeletal myotube maturation.

A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1.

In vitro generation of germ cells from murine embryonic stem cells.

Debugging cellular reprogramming.

Reprogramming of human somatic cells to pluripotency with defined factors.

Generation of human-induced pluripotent stem cells.

Disease-specific induced pluripotent stem cells.

Regulatory networks define phenotypic classes of human stem cell lines.

Human iPS cell derivation/reprogramming.

Generation of induced pluripotent stem cells from human blood.

Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells.

Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming.

Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1.

Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells.

A role for Lin28 in primordial germ-cell development and germ-cell malignancy.

Cardiomyocyte differentiation of human induced pluripotent stem cells.

Hematopoietic development from human induced pluripotent stem cells.

Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells.

Generation of functional human hepatic endoderm from human induced pluripotent stem cells.

Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts.

A robust approach to identifying tissue-specific gene expression regulatory variants using personalized human induced pluripotent stem cells.

Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells.

DYS-HAC-iPS cells: the combination of gene and cell therapy to treat duchenne muscular dystrophy.

Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients.

Robust enhancement of neural differentiation from human ES and iPS cells regardless of their innate difference in differentiation propensity.

Reprogramming of T cells from human peripheral blood.

Research highlights.

Five classic articles in somatic cell reprogramming.

Human pluripotent stem cells produce natural killer cells that mediate anti-HIV-1 activity by utilizing diverse cellular mechanisms.

Hematopoietic differentiation of induced pluripotent stem cells from patients with mucopolysaccharidosis type I (Hurler syndrome).

Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells.

MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states.

Analysis of differential proteomes of induced pluripotent stem cells by protein-based reprogramming of fibroblasts.

Induced pluripotent stem cells: a novel frontier in the study of human primary immunodeficiencies.

Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells.

Induced pluripotent stem cells for neural tissue engineering.

Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice.

Induced pluripotent stem cell models from X-linked adrenoleukodystrophy patients.

Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome.

Research highlights.

Cell cycle adaptations of embryonic stem cells.

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.

The lesser known story of X chromosome reactivation: a closer look into the reprogramming of the inactive X chromosome.

Human induced pluripotent stem cells and neurodegenerative disease: prospects for novel therapies.

Humanized murine model for HBV and HCV using human induced pluripotent stem cells.

Overcoming Reprogramming Resistance of Fanconi Anemia Cells.

Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability.