Chapter 6
Principles of Mass Spectrometry
Spectrométrie de masse : Vue d’ensemble
Mass spectrometry is an analytical technique used to determine the molecular mass and molecular formula of a compound. The basic principle of mass ...
Spectrométrie de masse : effet isotopique
Most elements exist in nature as a mixture of isotopes. The isotopes differ in weight due to their respective number of neutrons. The molecular weight of ...
Spectrométrie de masse : aperçu de la fragmentation moléculaire
The ionization of a molecule into a molecular ion inside the mass spectrometer causes instability in the molecule's structure due to the loss of an ...
Spectromètres de masse
This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record ...
Spectre de masse
A mass spectrum is the graphical representation of the relative abundance of the charged fragments in an analyte plotted against their mass-to-charge ...
Spectre de masse : interprétation
Given a known molecular ion mass, the unknown compound can be identified.
The empirical formula is determined from the molecular ion mass and the isotope ...
Analyseurs de masse : Vue d’ensemble
Common mass analyzers include magnetic sector, double-focusing, quadrupole, time-of-flight, and ion trap analyzers.
The capability of any mass analyzer ...
Analyseurs de masse : types courants
The quadrupole mass analyzer consists of four parallel rods, across which are applied a DC voltage and a radio-frequency AC voltage.
Here, the field ...
Spectrométrie de masse à haute résolution (HRMS)
The resolution of a mass spectrometer depends on the efficiency of separating ions with different ion masses. The mass of an atom is approximated to the ...
Spectrométrie de masse : analyse complexe
The analysis of complex mixtures requires the combination of separation methods and mass spectrometry in sequence, termed hyphenated methods.
GC–MS ...
Spectrométrie de masse en tandem
Tandem mass spectrometry, or MS/MS, combines two mass analyzers in sequence, connected by a collision or interaction cell.
First, the samples are ionized ...
Chromatographie en phase gazeuse – Spectrométrie de masse (GC-MS)
Gas chromatography–mass spectrometry (GC–MS) is the combination of analytical techniques of gas chromatography and mass spectrometry in a ...
Spectrométrie de masse à plasma à couplage inductif (ICP-MS) : vue d’ensemble
Inductively coupled plasma–mass spectrometry, or ICP–MS, uses an ICP source to prepare samples for atomic mass spectrometry.
Solution-state ...
Spectrométrie de masse à plasma à couplage inductif (ICP-MS) : interférences
Despite the advantages offered by ICP–MS, accurate elemental analysis is affected by spectroscopic and non-spectroscopic interferences.
...
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