S'identifier

The single-compartment model serves as a simplified representation of the human body. This model assumes that the body functions as a single, well-mixed open compartment. When a drug is administered intravenously, it enters the body and quickly distributes uniformly. The drug then undergoes biotransformation and elimination, ultimately leaving the body. The volume of this compartment is referred to as the apparent volume of distribution into which the drug can uniformly distribute. In this model, drug clearance from the body follows first-order kinetics, meaning that the elimination rate is directly proportional to the drug concentration in the body. With time, the drug plasma concentration declines exponentially, leading to a similar decline in tissue drug concentration. When a continuous infusion of a drug occurs, a steady-state value is reached exponentially. However, if the infusion stops, the concentration of the drug in the body falls exponentially. On the other hand, when a drug is administered in multiple equal doses, the average steady-state concentration and the time required to reach this steady state are comparable to those achieved with continuous infusion.

Tags
Compartment ModelsSingle compartment ModelHuman BodyDrug AdministrationIntravenous DrugBiotransformationEliminationVolume Of DistributionDrug ClearanceFirst order KineticsPlasma ConcentrationTissue ConcentrationContinuous InfusionSteady state ConcentrationMultiple Doses

Du chapitre 3:

article

Now Playing

3.13 : Compartment Models: Single-Compartment Model

Pharmacokinetics

1.9K Vues

article

3.1 : Pharmacocinétique : Vue d’ensemble

Pharmacokinetics

4.6K Vues

article

3.2 : Mécanisme d’absorption du médicament : transport membranaire passif

Pharmacokinetics

3.2K Vues

article

3.3 : Mécanisme d’absorption du médicament : transport membranaire médié par le transporteur

Pharmacokinetics

3.1K Vues

article

3.4 : Absorption des médicaments : facteurs affectant l’absorption gastro-intestinale

Pharmacokinetics

3.4K Vues

article

3.5 : Biodisponibilité : Vue d’ensemble

Pharmacokinetics

2.3K Vues

article

3.6 : Facteurs influençant la biodisponibilité : élimination au premier passage

Pharmacokinetics

5.7K Vues

article

3.7 : Bioéquivalence : Vue d’ensemble

Pharmacokinetics

842 Vues

article

3.8 : Effet de premier passage

Pharmacokinetics

4.7K Vues

article

3.9 : Évolution temporelle de l’effet du médicament

Pharmacokinetics

1.8K Vues

article

3.10 : Distribution du médicament : liaison tissulaire

Pharmacokinetics

2.3K Vues

article

3.11 : Barrières physiologiques

Pharmacokinetics

3.1K Vues

article

3.12 : Distribution du médicament : liaison aux protéines plasmatiques

Pharmacokinetics

3.8K Vues

article

3.14 : Modèles à compartiments : Modèle à deux compartiments

Pharmacokinetics

4.8K Vues

article

3.15 : Distribution des médicaments : Volume de distribution

Pharmacokinetics

3.5K Vues

See More

JoVE Logo

Confidentialité

Conditions d'utilisation

Politiques

Recherche

Enseignement

À PROPOS DE JoVE

Copyright © 2025 MyJoVE Corporation. Tous droits réservés.