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Unilateral Pyramidotomy of the Corticospinal Tract in Rats for Assessment of Neuroplasticity-inducing Therapies

DOI :

10.3791/51843-v

8:41 min

December 15th, 2014

December 15th, 2014

15,354 Views

1Neurorestoration, Wolfson Centre for Age-Related Diseases, King's College London, 2Department of Neuroscience, Baylor College of Medicine

The corticospinal tract, one of the major sensorimotor tracts, can be lesioned unilaterally in the rodent brainstem in order to test neuroplasticity-inducing therapies for the central nervous system. This surgical procedure (“pyramidotomy”) and postoperative assessments are described in this protocol.

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Keywords Corticospinal Tract

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