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Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease

DOI :

10.3791/55599-v

April 17th, 2017

April 17th, 2017

12,344 Views

1Neuroscience Graduate Program, University of Cincinnati, 2Department of Biological Sciences, Wright State University, 3Division of Neurosurgery, Cincinnati Children's Hospital Medical Center

This paper introduces a method for repeated measurements of ventilation and respiratory muscle activity in a freely behaving amyotrophic lateral sclerosis (ALS) mouse model throughout disease progression with whole-body plethysmography and electromyography via an implanted telemetry device.

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