Results: Use of an In Vitro Method to Study Endothelial-mesenchymal Transition Upon TGF-β Treatment
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This method can help answer key questions in vascular and cancer biology fields, such as mechanisms of endothelial plasticity in various pathological conditions, including cancer. The main advantage of this technique is that robust induction of in
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A protocol for in vitro induction of endothelial-mesenchymal transition (EndMT), which is useful for investigating cellular signaling pathways involved in EndMT, is described. In this experimental model, EndMT is induced by treatment with TGF-β in MS-1 endothelial cells.