Differential Scanning Calorimetry (DSC): Sample Preparation and Measurement
3:00
Differential Scanning Calorimetry (DSC): Data Analysis
4:38
Small and Wide-Angle X-Ray Scattering (SWAXS)
8:11
Results: Correlation Between Solid State Alteration of Lipids and API Release from Different Lipid-Based Dosage Forms
10:39
Conclusion
Transcription
The combination of differential scanning calorimetry and x-ray diffraction is a gold standard for investigated solid-state alterations of lipid-based pharmaceutical products. The combined methodology is a strong tool for screening the polymorphism
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This publication shows the application of x-ray diffraction and differential scanning calorimetry as gold standards for investigating the solid-state of lipid-based excipients (LBEs). Understanding the solid-state alteration in LBEs and its effect on the performance of pharmaceutical products thereof is the key factor for manufacturing robust lipid-based dosage forms.