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Center for Discovery and Innovation
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PanD Structure-Function Analysis and Identification of a Potent Pyrazinoic Acid-Derived Enzyme Inhibitor.
ACS chemical biology Jun, 2021 | Pubmed ID: 33984234
Piperidine-4-Carboxamides Target DNA Gyrase in Mycobacterium abscessus.
Antimicrobial agents and chemotherapy Jul, 2021 | Pubmed ID: 34001512
Reinvestigation of the structure-activity relationships of isoniazid.
Tuberculosis (Edinburgh, Scotland) Jul, 2021 | Pubmed ID: 34116482
Potency boost of a dihydrofolate reductase inhibitor by multienzyme FH-dependent reduction.
Proceedings of the National Academy of Sciences of the United States of America Jun, 2021 | Pubmed ID: 34161270
A Mycobacterium tuberculosis NBTI DNA Gyrase Inhibitor Is Active against Mycobacterium abscessus.
Antimicrobial agents and chemotherapy Nov, 2021 | Pubmed ID: 34606340
Cyclohexyl-griselimycin Is Active against Mycobacterium abscessus in Mice.
Antimicrobial agents and chemotherapy Jan, 2022 | Pubmed ID: 34723632
Resistance against DNA Gyrase Inhibitor SPR719 in Mycobacterium avium and Mycobacterium abscessus.
Microbiology spectrum Feb, 2022 | Pubmed ID: 35019671
A Rabbit Model to Study Antibiotic Penetration at the Site of Infection for Nontuberculous Mycobacterial Lung Disease: Macrolide Case Study.
Antimicrobial agents and chemotherapy Mar, 2022 | Pubmed ID: 35099272
Structural and Mechanistic Insights into Aspartate Decarboxylase PanD and a Pyrazinoic Acid-Derived Inhibitor.
ACS infectious diseases Jul, 2022 | Pubmed ID: 35731701
Side-by-Side Profiling of Oxazolidinones to Estimate the Therapeutic Window against Mycobacterial Infections.
Antimicrobial agents and chemotherapy Apr, 2023 | Pubmed ID: 36920191
Synthesis and Characterization of Phenylalanine Amides Active against and Other Mycobacteria.
Journal of medicinal chemistry Apr, 2023 | Pubmed ID: 37001025
Characterization of Resistance to Linezolid in Mycobacterium abscessus.
Microbiology spectrum Aug, 2023 | Pubmed ID: 37458588
Pharmacological validation of dihydrofolate reductase as a drug target in .
Antimicrobial agents and chemotherapy Jan, 2024 | Pubmed ID: 38018963
A pairwise approach to revitalize β-lactams for the treatment of TB.
Antimicrobial agents and chemotherapy Jun, 2024 | Pubmed ID: 38690896
Multidrug tolerance conferred by loss-of-function mutations in anti-sigma factor RshA of .
Antimicrobial agents and chemotherapy Dec, 2024 | Pubmed ID: 39470195
Durlobactam to boost the clinical utility of standard of care β-lactams against lung disease.
Antimicrobial agents and chemotherapy Jan, 2025 | Pubmed ID: 39565116
Hackensack Meridian Health
Julianna Proietto*,1,
Betelhem Tatek*,1,
Camilla Folvar*,1,
Diana C. Jimenez2,
Ilham M. Alshiraihi2,3,
Mercedes Gonzalez-Juarrero2,
Fabio Saliu4,
Federica Vacca4,
Daniela Maria Cirillo4,
Nicolà Lore4,
Thomas Dick1,5,6,
Véronique Dartois1,5,
Wassihun Wedajo Aragaw1
1Center for Discovery and Innovation, Hackensack Meridian Health,
2Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University,
3Department of Biological Sciences, College of Science, University of Tabuk,
4Emerging Bacterial Pathogens Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute,
5Department of Medical Sciences, Hackensack Meridian School of Medicine,
6Department of Microbiology and Immunology, Georgetown University
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