Using Reference Reagents to Confirm Robustness of Cytokine Release Assays for the Prediction of Monoclonal Antibody SafetyElliot MacLeod 1, Deepa Rajagopal 1, Sandrine Vessillier 1
1The Medicines and Healthcare Products Regulatory Agency (MHRA)
The use of cytokine release assay reference reagents allows for more reproducible and standardized in vitro safety profiles of immunotherapeutic monoclonal antibodies. Here we describe how cytokine release assays can be used alongside a reference reagent panel to predict the safety of some therapeutic monoclonal antibodies.
