Zhejiang Normal University

1 ARTICLES PUBLISHED IN JoVE

Neuroscience

Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid Percussion

Yunchen Liu^*1, Haojie Mao^*1, Shiqiang Chen¹, Jihui Wang¹, Wei Ouyang¹

¹College of Physical Education and Health Sciences, Zhejiang Normal University

This protocol presents a modified mouse model of repetitive mild traumatic brain injury (rmTBI) induced via a closed-head injury (CHI) method. The approach features a thinned-skull window and fluid percussion to reduce the inflammation commonly caused by meninges exposure, along with improved reproducibility and accuracy in modeling rmTBI in rodents.