Modified Mouse Model of Repetitive Mild Traumatic Brain Injury Incorporating Thinned-Skull Window and Fluid PercussionYunchen Liu *1, Haojie Mao *1, Shiqiang Chen 1, Jihui Wang 1, Wei Ouyang 1
1College of Physical Education and Health Sciences, Zhejiang Normal University
This protocol presents a modified mouse model of repetitive mild traumatic brain injury (rmTBI) induced via a closed-head injury (CHI) method. The approach features a thinned-skull window and fluid percussion to reduce the inflammation commonly caused by meninges exposure, along with improved reproducibility and accuracy in modeling rmTBI in rodents.
