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University of Medicine and Pharmacy

3 ARTICLES PUBLISHED IN JoVE

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Medicine

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Sakine Simsekyilmaz 1, Fabian Schreiber 2, Stefan Weinandy 3, Felix Gremse 4, Tolga Taha Sönmez 5, Elisa A. Liehn 1
1Institute for Molecular Cardiovascular Research, RWTH Aachen University, 2Institute for Textile Technology and Mechanical Engineering, RWTH Aachen University, 3Institute for Applied Medical Engineering, Helmholtz-Institute of RWTH Aachen University, 4Department of Experimental Molecular Imaging, RWTH Aachen University, 5Department of Oral and Maxillofacila Surgery, RWTH Aachen University

A model of stent implantation in mouse carotid artery is described. Compared to other similar methods, this procedure is very rapid, simple and accessible, offering the possibility to study in a convenient way the vascular wall reaction to different drug-eluting stents and the molecular mechanisms of restenosis.

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Medicine

Induction of Accelerated Atherosclerosis in Mice: The "Wire-Injury" Model
Adelina Curaj 1, Wu Zhoujun 1, Mareike Staudt 1, Elisa A. Liehn 1,2
1Institute for Molecular Cardiovascular Research, RWTH Aachen University, 2Human Genetic Laboratory, University of Medicine and Pharmacy

This study describes an invasive procedure for the induction of accelerated atherosclerosis in mice. In comparison to other methods using electric- or cryo-induced injury, mechanical-induced injury mimics the human condition of restenosis after revascularization therapies and is ideal for the study of the molecular mechanisms involved.

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Medicine

Using the Sleeve Technique in a Mouse Model of Aortic Transplantation - An Instructional Video
Zuzanna Rowinska 1,2, Simone Gorressen 3, Marc W. Merx 4, Thomas A. Koeppel 5, Alma Zernecke 6, Elisa A. Liehn 2
1Department of Vascular Surgery and Interdisciplinary Vein Center, St. Josef-Hospital, Ruhr- University Bochum, 2Institute of Molecular Cardiovascular Research, University Hospital, RWTH Aachen University Department of Medicine, 3Institute of Pharmacology and Clinical Pharmacology, Düsseldorf University Hospital, 4Department of Cardiology, Vascular Medicine and Intensive Care Medicine, Hospital Robert Koch Gehrden, 5Division of Vascular Surgery, Asklepios Klinik St. Georg, 6Institute of Experimental Biomedicine, Würzburg University

We present an orthotopic aortic transplantation model using the sleeve technique in mice. It is a very rapid anastomosis method, which can be employed in studies of vascular disease.

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