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Creighton University School of Dentistry

1 ARTICLES PUBLISHED IN JoVE

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Genetics

Inducible and Reversible Dominant-negative (DN) Protein Inhibition
Shikha Tarang 1, Umesh Pyakurel 1, Songila M.S.R. Doi 1, Michael D. Weston 1, Sonia M. Rocha-Sanchez 1
1Department of Oral Biology, Creighton University School of Dentistry

Here we present a protocol to develop a dominant-negative inducible system, in which any protein can be conditionally inactivated by reversibly overexpressing a dominant-negative mutant version of it.

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