CN Bio Innovations Ltd

1 ARTICLES PUBLISHED IN JoVE

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Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro

Ovidiu Novac¹, Raul Silva¹, Lucy-May Young¹, Kim Lachani¹, David Hughes¹, Tomasz Kostrzewski¹

Drug-induced liver injury (DILI) is a major cause of drug failure. A protocol has been developed to accurately predict the DILI liability of a compound using a liver microphysiological system (MPS). The liver model uses the coculture of primary hepatic cells and translationally relevant endpoints to assess cellular responses to treatment.