Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In VitroOvidiu Novac 1, Raul Silva 1, Lucy-May Young 1, Kim Lachani 1, David Hughes 1, Tomasz Kostrzewski 1
1CN Bio Innovations Ltd
Drug-induced liver injury (DILI) is a major cause of drug failure. A protocol has been developed to accurately predict the DILI liability of a compound using a liver microphysiological system (MPS). The liver model uses the coculture of primary hepatic cells and translationally relevant endpoints to assess cellular responses to treatment.
