A High-throughput Automated Platform for the Development of Manufacturing Cell Lines for Protein TherapeuticsShuangping Shi 1, Russ G.G. Condon 1, Liang Deng 1, Jason Saunders 1, Finn Hung 1, Yung-Shyeng Tsao 1, Zhong Liu 1
1Merck Research Laboratory, Merck & Co., Inc
A high-throughput, automated platform of manufacturing cell line development for producing protein therapeutics is described. Implementation of BD FACS Aria Cell Sorter, CloneSelect Imager and TECAN Freedom EVO liquid handling system has demonstrated significantly increased processing capacity in cell line development with improved cell line quality and high reproducibility.
