Charité - Universitätsmedizin Berlin, Germany

2 ARTICLES PUBLISHED IN JoVE

Medicine

Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia

Lukas Julius Speetzen¹, Matthias Endres¹, Alexander Kunz¹

¹Department of Neurology, Center for Stroke Research Berlin, Charité - Universitätsmedizin Berlin, Germany

There is accumulating evidence, that ischemic preconditioning (PC) – a non-damaging ischemic challenge to the brain - confers a transient protection to a subsequent damaging ischemic insult. We established bilateral common carotid artery occlusion (BCCAO) as a preconditioning stimulus to induce early ischemic tolerance (IT) to transient focal cerebral ischemia (induced by middle cerebral artery occlusion, MCAO) in C57Bl6/J mice.

Medicine

Prehospital Thrombolysis: A Manual from Berlin

Martin Ebinger^1,2,5, Sascha Lindenlaub^1,3,5, Alexander Kunz^1,2,5, Michal Rozanski^2,5, Carolin Waldschmidt^2,5, Joachim E. Weber^2,5, Matthias Wendt^2,5, Benjamin Winter^1,2,5, Philipp A. Kellner^4,5, Sabina Kaczmarek^4,5, Matthias Endres^1,2,5, Heinrich J. Audebert^1,2,5

¹Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin Berlin, ²Klinik und Hochschulambulanz für Neurologie, Charité - Universitätsmedizin Berlin, ³Medical School of the Universität Hamburg, Universitätsklinikum Hamburg - Eppendorf, ⁴Berliner Feuerwehr, ⁵STEMO-Consortium

Identification of suspected stroke in the dispatch center of the Berlin Fire Brigade prompts the deployment of a CT-equipped ambulance. If ischemic stroke is confirmed and contraindications are excluded prehospital thrombolysis is applied.