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Kennedy Krieger Institute

4 ARTICLES PUBLISHED IN JoVE

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Medicine

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
Jennifer L. Keller 1, Nora Fritz 1,2, Chen Chun Chiang 1, Allen Jiang 1, Tziporah Thompson 3, Nicole Cornet 1, Scott D. Newsome 4, Peter A. Calabresi 4, Kathleen Zackowski 1,2,4
1Motion Analysis Laboratory, Kennedy Krieger Institute, 2Physical Medicine & Rehabilitation, Johns Hopkins University School of Medicine, 3Johns Hopkins University School of Medicine, 4Department of Neurology, Johns Hopkins University School of Medicine

Hip weakness is a common symptom affecting walking ability in people with multiple sclerosis. Isolated muscle strengthening is a useful method to target specific weaknesses. This protocol describes a progressive resistance-training program using exercise bands to increase hip muscle strength.

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Neuroscience

Online Transcranial Magnetic Stimulation Protocol for Measuring Cortical Physiology Associated with Response Inhibition
Michael D. Guthrie 1, Donald L. Gilbert 2, David A. Huddleston 2, Ernest V. Pedapati 2,3, Paul S. Horn 2, Stewart H. Mostofsky 4, Steve W. Wu 2
1College of Medicine, University of Cincinnati, 2Division of Neurology, Cincinnati Children's Hospital Medical Center, 3Division of Psychiatry, Cincinnati Children's Hospital Medical Center, 4Center for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute

We describe an experimental procedure to quantify excitability and inhibition of primary motor cortex during a motor response inhibition task by using Transcranial Magnetic Stimulation throughout the course of a Stop Signal Task.

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Medicine

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
Dan Wu 1, Andreia V. Faria 1, Laurent Younes 2,3,4, Christopher A. Ross 5, Susumu Mori 1,6, Michael I. Miller 2,3,7
1The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 2Center for Imaging Science, Johns Hopkins University, 3Institute for Computational Medicine, Johns Hopkins University, 4Department of Applied Mathematics and Statistics, Johns Hopkins University, 5Division of Neurobiology, Departments of Psychiatry, Neurology, Neuroscience and Pharmacology, and Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, 6F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, 7Department of Biomedical Engineering, Johns Hopkins University

This paper describes a statistical model for volumetric MRI data analysis, which identifies the "change-point" when brain atrophy begins in premanifest Huntington's disease. Whole-brain mapping of the change-points is achieved based on brain volumes obtained using an atlas-based segmentation pipeline of T1-weighted images.

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Developmental Biology

Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice
Kyla A. Britson 1,2, Aaron D. Black 2,3, Kathryn R. Wagner 1,2,3,4, Thomas E. Lloyd 1,2,4
1Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, 2Department of Neurology, Johns Hopkins University School of Medicine, 3Kennedy Krieger Institute, 4Department of Neuroscience, Johns Hopkins University School of Medicine

Complex human diseases can be challenging to model in traditional laboratory model systems. Here, we describe a surgical approach to model human muscle disease through the transplantation of human skeletal muscle biopsies into immunodeficient mice.

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