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Performing Human Skeletal Muscle Xenografts in Immunodeficient Mice

DOI :

10.3791/59966-v

September 16th, 2019

September 16th, 2019

9,382 Views

1Graduate Program in Cellular and Molecular Medicine, Johns Hopkins University School of Medicine, 2Department of Neurology, Johns Hopkins University School of Medicine, 3Kennedy Krieger Institute, 4Department of Neuroscience, Johns Hopkins University School of Medicine

Complex human diseases can be challenging to model in traditional laboratory model systems. Here, we describe a surgical approach to model human muscle disease through the transplantation of human skeletal muscle biopsies into immunodeficient mice.

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Keywords Human Skeletal Muscle Xenografts

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