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Centre de recherche UGA - INSERM U1209 - CNRS UMR

1 ARTICLES PUBLISHED IN JoVE

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Biology

Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic Beads
Angélique Millon-Frémillon *1, Julien Aureille *1, Christophe Guilluy 1
1Institute for Advanced Biosciences, Centre de recherche UGA - INSERM U1209 - CNRS UMR

Cell surface adhesions are central in mechanotransduction, as they transmit mechanical tension and initiate the signaling pathways involved in tissue homeostasis and development. Here, we present a protocol for dissecting the biochemical pathways that are activated in response to tension, using ligand-coated magnetic microbeads and force application to adhesion receptors.

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