Analyzing Cell Surface Adhesion Remodeling in Response to Mechanical Tension Using Magnetic BeadsAngélique Millon-Frémillon *1, Julien Aureille *1, Christophe Guilluy 1
1Institute for Advanced Biosciences, Centre de recherche UGA - INSERM U1209 - CNRS UMR
Cell surface adhesions are central in mechanotransduction, as they transmit mechanical tension and initiate the signaling pathways involved in tissue homeostasis and development. Here, we present a protocol for dissecting the biochemical pathways that are activated in response to tension, using ligand-coated magnetic microbeads and force application to adhesion receptors.
