Chinese Academy of Medical Science & Peking Union Medical College

2 ARTICLES PUBLISHED IN JoVE

Bioengineering

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating

Jingyi Yang¹, Shaofeng Lou¹, Deling Kong¹, Chen Li¹

¹Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Science & Peking Union Medical College

This protocol aims to achieve surface engineering of pancreatic islets using a heparin-incorporated starPEG nanocoating via pseudo-bioorthogonal chemistry between the N-hydroxysuccinimide groups of the nanocoating and the amine groups of islet cell membrane.

Biology

Implantation of Electrospun Vascular Grafts with Optimized Structure in a Rat Model

Kang Qin¹, Yifan Wu¹, Yiwa Pan¹, Kai Wang¹, Deling Kong¹, Qiang Zhao¹

¹State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials (Ministry of Education), College of Life Sciences, Nankai University

Here, we present a modified electrospinning method to fabricate PCL vascular grafts with thick fibers and large pores, and describe a protocol to evaluate the in vivo performance in a rat model of abdominal aorta replacement.