University of Padua School of Medicine

1 ARTICLES PUBLISHED IN JoVE

Biology

De Novo Generation of Somatic Stem Cells by YAP/TAZ

Tito Panciera¹, Luca Azzolin¹, Daniele Di Biagio¹, Antonio Totaro¹, Michelangelo Cordenonsi¹, Stefano Piccolo¹

¹Department of Molecular Medicine, University of Padua School of Medicine

Availability of somatic SCs is crucial for regenerative medicine, disease modeling and to gain insight into SC properties. Here we present experimental strategies to reprogram, in vitro, differentiated adult cells into their corresponding expandable tissue-specific stem/progenitor cells by the transient expression of the single transcriptional co-activator YAP.