De Novo Generation of Somatic Stem Cells by YAP/TAZTito Panciera 1, Luca Azzolin 1, Daniele Di Biagio 1, Antonio Totaro 1, Michelangelo Cordenonsi 1, Stefano Piccolo 1
1Department of Molecular Medicine, University of Padua School of Medicine
Availability of somatic SCs is crucial for regenerative medicine, disease modeling and to gain insight into SC properties. Here we present experimental strategies to reprogram, in vitro, differentiated adult cells into their corresponding expandable tissue-specific stem/progenitor cells by the transient expression of the single transcriptional co-activator YAP.
