Universitätsmedizin Greifswald

2 ARTICLES PUBLISHED IN JoVE

Immunology and Infection

Colon Ascendens Stent Peritonitis (CASP) - a Standardized Model for Polymicrobial Abdominal Sepsis

Tobias Traeger^*1, Pia Koerner^*1, Wolfram Kessler¹, Katharina Cziupka¹, Stephan Diedrich¹, Alexandra Busemann¹, Claus-Dieter Heidecke¹, Stefan Maier¹

¹Department of Surgery, University of Greifswald

The Colon Ascendens Stent Peritonitis (CASP) is a highly standardized model for polymicrobial abdominal sepsis in rodents. This article describes the surgical procedure of CASP. The CASP model and its variants allow the systematic investigation of various problems concerning the subject of sepsis.

Medicine

Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

Annabel Kleinwort¹, Paula Döring², Christine Hackbarth¹, Maciej Patrzyk¹, Claus-Dieter Heidecke¹, Tobias Schulze¹

¹Department of General Surgery, Visceral, Thoracic and Vascular Surgery, Universitätsmedizin Greifswald, ²Institute of Pathology, Universitätsmedizin Greifswald

Murine distal colostomy provides a murine model for human diversion colitis, a predominantly lymphocytic colitis in colon segment excluded from the fecal stream.