<p class="jove_content">Measurements of drug target engagement are central to effective drug development and chemical probe validation. Here, we detail a protocol for measuring drug-target engagement using high content imaging in a microplate-compatible adaption of the cellular thermal shift assay (CETSA).</p>

using-high-content-imaging-to-quantify-target-engagement-adherent

Using High Content Imaging to Quantify Target Engagement in Adherent Cells

Quantitating the interaction of small molecules with their intended protein target is critical for drug development, target validation and chemical probe ...

Institution - Karolinska Institutet, Solna

Articles Published in JoVE