Fralin Biomedical Research Institute at Virginia Tech Carilion

1 ARTICLES PUBLISHED IN JoVE

Behavior

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

¹Fralin Biomedical Research Institute at Virginia Tech Carilion, ²School of Neuroscience, Virginia Tech, ³Department of Biological Sciences, Virginia Tech

This systematic protocol describes a new animal model of post-traumatic epilepsy after repetitive mild traumatic brain injury. The first part details steps for traumatic brain injury induction using a modified weight drop model. The second part provides instructions on the surgical approach for single- and multi-channel electroencephalographic data acquisition systems.