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Keene State College

2 ARTICLES PUBLISHED IN JoVE

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Education

Preparation of SNS Cobalt(II) Pincer Model Complexes of Liver Alcohol Dehydrogenase
John R. Miecznikowski 1, Jerry P. Jasinski 2, Manpreet Kaur 2, Sheila C. Bonitatibus 1, Emilse M. Almanza 1, Rami M. Kharbouch 1, Samantha E. Zygmont 1, Kendra R. Landy 1
1Department of Chemistry and Biochemistry, Fairfield University, 2Department of Chemistry, Keene State College

The preparation of SNS pincer cobalt(II) model complexes of liver alcohol dehydrogenase is presented here. The complexes can be prepared by reacting the ligand precursor with CoCl2·6H2O and can then be recrystallized by allowing diethyl ether to slowly diffuse into an acetonitrile solution that contains the cobalt complex.

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Immunology and Infection

Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury
Jessica Andrea Brocos Duda 1, Manpreet Kaur 1, Gurpreet K. Aulakh 1
1Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan

Combined ozone and bacterial endotoxin exposed mice show wide-spread cell death, including that of neutrophils. We observed cellular adaptations such as disruption of cytoskeletal lamellipodia, increased cellular expression of complex V ATP synthase subunit β and angiostatin in broncho-alveolar lavage, suppression of the lung immune response and delayed neutrophil recruitment.

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