Institute for Risk Assessment Sciences (IRAS)

1 ARTICLES PUBLISHED IN JoVE

Biology

An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing

Hedwig M. Braakhuis¹, Ruiwen He^1,2, Rob J. Vandebriel¹, Eric R. Gremmer¹, Edwin Zwart¹, Jolanda P. Vermeulen¹, Paul Fokkens¹, John Boere¹, Ilse Gosens¹, Flemming R. Cassee^1,2

¹National Institute for Public Health and the Environment (RIVM), ²Institute for Risk Assessment Sciences (IRAS)

Described is the cell culture and exposure method of an in vitro bronchial model for realistic, repeated inhalation exposure to particles for toxicity testing.