University of St. Andrews

1 ARTICLES PUBLISHED IN JoVE

Neuroscience

Dorsal Root Ganglion Injection and Dorsal Root Crush Injury as a Model for Sensory Axon Regeneration

Menghon Cheah¹, James W. Fawcett¹, Melissa R. Andrews^2,3

¹John van Geest Center for Brain Repair, University of Cambridge, ²School of Medicine, University of St. Andrews, ³Department of Biological Sciences, University of Southampton

This protocol presents the use of a dorsal root ganglion (DRG) injection with a viral vector and a concurrent dorsal root crush injury in an adult rat as a model to study sensory axon regeneration. This model is suitable for investigating the use of gene therapy to promote sensory axon regeneration.